左甲状腺素对妊娠合并甲状腺功能减退症患者妊娠结局及后代智力的影响  

Effects of Levothyroxine on Pregnancy Outcomes and Offspring Intelligence in Pregnant Patients with Hypothyroidism

作　　者：李涛[1] LI Tao(Department of Obstetrics,Jinan Third People’s Hospital,Jinan 250000,China)

机构地区：[1]山东省济南市第三人民医院产科,山东济南250000

出　　处：《中国伤残医学》2024年第22期10-13,共4页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨左甲状腺素(LT4)治疗对妊娠期甲状腺功能减退症(甲减)患者妊娠结局及后代智力的影响。方法:选取2022年6月-2023年10月济南市第三人民医院收治的80例妊娠合并甲减患者为研究对象,随机将其分为研究组及对照组,各40例。研究组接受LT4治疗,对照组未接受特殊治疗。比较两组妊娠结局、后代智力发育,并评估研究组LT4治疗效果。结果:研究组的妊娠期高血压疾病、流产、早产及低出生体重儿发生率分别为5.00%、2.50%、7.50%、2.50%,均低于对照组的20.00%、15.00%、25.00%、15.00%,差异均有统计学意义(P<0.05)。干预后,研究组的新生儿神经行为评分、儿童智力测试评分及语言和运动能力评估评分均高于对照组,差异均有统计学意义(P<0.05)。干预后,研究组的血清促甲状腺激素水平低于干预前,游离甲状腺素水平高于干预前,差异均有统计学意义(P<0.05)。结论:妊娠合并甲减患者的早期诊断和治疗至关重要,LT4治疗能改善其妊娠结局及后代智力发育情况。Objective:To investigate the effects of levothyroxine(LT4)on pregnancy outcomes and offspring intelligence in pregnant patients with hypothyroidism.Methods:A total of 80 pregnant patients with hypothyroidism treated in Jinan Third People’s Hospital from June 2022 to October 2023 were selected as the study objects and were randomly divided into a study group and a control group,with 40 cases in each group.The study group received LT4 treatment,while the control group received no specific treatment.The pregnancy outcome and offspring intellectual development of the two groups were compared,and the LT4 treatment effect of the study group was evaluated.Results:The incidence of pregnancy-induced hypertension,abortion,premature delivery and low birth weight infants in the study group were 5.00%,2.50%,7.50%and 2.50%,respectively,which were lower than 20.00%,15.00%,25.00%and 15.00%in the control group,the differences were statistically significant(P<0.05).After intervention,the neonatal neurobehavioral score,intelligence test score and language and motor ability assessment score of the study group were higher than those of the control group,and the differences were statistically significant(P<0.05).After intervention,the level of serum thyrotropin in the study group was lower than before intervention,and the level of free thyroxine was higher than before intervention,the differences between the groups were statistically significant(P<0.05).Conclusion:Early diagnosis and treatment of pregnant patients with hypothyroidism are very important,LT4 treatment can improve the pregnancy outcome and offspring intellectual development.

关 键 词：甲状腺功能减退症 妊娠 左甲状腺素 妊娠结局 后代智力 

分 类 号：R714.2[医药卫生—妇产科学]