低分子肝素续贯利伐沙班治疗肺栓塞患者的效果分析  

Effect Analysis of Low Molecular Heparin Sequential Rivaroxaban in the Treatment of Pulmonary Embolism Patients

作　　者：孙婷婷[1] 韩光[1] SUN Tingting;HAN Guang(Department of Respiratory and Critical Care Medicine,Jiangsu Province(Suqian)Hospital,Suqian 223800,China)

机构地区：[1]江苏省人民医院宿迁医院呼吸与危重症医学科,江苏宿迁223800

出　　处：《中国伤残医学》2024年第22期14-17,共4页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨低分子肝素续贯利伐沙班治疗肺栓塞患者的效果。方法:回顾性分析2021年1月-2023年12月江苏省人民医院宿迁医院收治的60例肺栓塞患者的临床资料,所有患者均采用低分子肝素续贯利伐沙班治疗,治疗时间为3个月。分析患者的症状缓解时间,生命体征、心肌标记物、凝血功能的变化情况。结果:经治疗,60例患者呼吸困难及发绀分别于(5.56±1.12)d、(6.35±1.24)d得到缓解。治疗后,患者的呼吸频率、心率均低于治疗前,PaO2高于治疗前,差异均有统计学意义(P<0.05)。治疗后,患者的N末端脑钠肽前体、肌钙蛋白Ⅰ均低于治疗前,差异均有统计学意义(P<0.05)。治疗后,患者D-二聚体指标低于治疗前,差异有统计学意义(P<0.05)。结论:使用低分子肝素续贯利伐沙班治疗肺栓塞患者可改善生命体征、凝血功能指标、心肌标记物指标,缓解临床症状,且临床效果较佳。Objective:To investigate the effect of Low Molecular Heparin sequential Rivaroxaban in the treatment of patients with pulmonary embolism.Methods:The clinical data of 60 patients with pulmonary embolism admitted to Jiangsu Province(Suqian)Hospital from January 2021 to December 2023 were retrospectively analyzed,all patients were treated with Low Molecular Heparin sequential Rivaroxaban for 3 months.Symptom remission time and changes in vital signs,myocardial markers and coagulation function were analyzed.Results:After treatment,dyspnea and cyanosis were relieved at(5.56±1.12)d and(6.35±1.24)d,respectively.After treatment,the respiratory rate and heart rate of patients were lower than before treatment,and PaO2 was higher than before treatment,with statistical significance(P<0.05).After treatment,the levels of N-terminal brain natriuretic peptide precursors and troponinⅠwere lower than those before treatment,with statistical significance(P<0.05).After treatment,the D-dimer indexes of patients was lower than before treatment,with statistical significance(P<0.05).Conclusion:The use of Low Molecular Heparin sequential Rivaroxaban in the treatment of pulmonary embolism patients can improve vital signs,coagulation function indicators,myocardial markers and alleviate clinical symptoms,and the clinical effect is good.

关 键 词：肺栓塞 低分子肝素 症状缓解时间 利伐沙班 心肌标记物 生命体征 

分 类 号：R56[医药卫生—呼吸系统]