右美托咪定持续泵注对腹腔镜全子宫切除术患者麻醉效果的影响分析  

Analysis of the Effect of Continuous Injection of Dexmedetomidine on Analgesia in Patients Undergoing Laparoscopic Total Hysterectomy

作　　者：马菲菲 MA Feifei(Department of Anesthesia Surgery,Jinan Third People’s Hospital,Jinan 250000,China)

机构地区：[1]山东省济南市第三人民医院麻醉手术科,山东济南250000

出　　处：《中国伤残医学》2024年第22期26-30,共5页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探究右美托咪定持续泵注对腹腔镜全子宫切除术患者镇静、镇痛效果的影响。方法:选取2022年5月-2024年4月于济南市第三人民医院行腹腔镜全子宫切除术治疗的80例患者为研究对象,随机分为对照组及研究组,各40例。研究组在麻醉诱导前15 min静脉泵注右美托咪定,后持续泵注到手术结束前30 min,对照组以相同方法输注等量生理盐水。比较两组患者的麻醉效果。结果:麻醉诱导后(T_(1))、气管插管时(T_(2))、手术开始时(T_(3))时,两组平均动脉压、心率均产生一定波动,但研究组的波动幅度更小,差异均有统计学意义(P<0.05)。研究组的苏醒时间、拔管时间、呼吸恢复时间均短于对照组,差异均有统计学意义(P<0.05)。入室后(T_(0))及T_(1)、T_(2)、T_(3)时,研究组的丙二醛、总抗氧化态水平的波动幅度均明显低于对照组,差异均有统计学意义(P<0.05)。研究组的Ricker镇静躁动评分比对照组低,Ramsay镇静评分比对照组高,差异均有统计学意义(P<0.05)。术后12 h、1 d、3 d,研究组的疼痛视觉模拟评分法评分均比对照组低,差异均有统计学意义(P<0.05)。结论:将右美托咪定应用于腹腔镜全子宫切除术麻醉中可获得理想的镇静、镇痛效果,加快患者术后恢复速度,维持患者各项体征稳定。Objective:To investigate the effect of continuous injection of dexmedetomidine on sedation and analgesia in patients undergoing laparoscopic total hysterectomy.Methods:A total of 80 patients who underwent laparoscopic total hysterectomy in Jinan Third People’s Hospital from May 2022 to April 2024 were selected as the study objects and were randomly divided into a control group and a study group,with 40 patients in each group.The study group was injected with dexmedetomidine intravenously 15 min before anesthesia induction,and then continued to pump until 30 min before the end of surgery,while the control group was injected with the same amount of normal saline in the same way.The anesthetic effects of the two groups were compared.Results:After anesthesia induction(T_(1)),at tracheal intubation(T_(2))and at the beginning of surgery(T_(3)),the mean arterial pressure and heart rate of the two groups had certain fluctuations,but the fluctuation amplitudes of the study group were smaller,and the differences were statistically significant(P<0.05).The recovery time,extubation time and respiratory recovery time of the study group were shorter than those of the control group,and the differences were statistically significant(P<0.05).After entry(T_(0)),T_(1),T_(2)and T_(3),the fluctuation ranges of malondialdehyde and total antioxidant state levels in the study group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).The score of Ricker sedative agitation in the study group was lower than that in the control group,and the score of Ramsay sedative agitation was higher than that in the control group,the differences were statistically significant(P<0.05).At 12 h,1 d and 3 d after surgery,the pain visual analogue scale scores of the study group were lower than those of the control group,and the differences were statistically significant(P<0.05).Conclusion:The application of dexmedetomidine in the anesthesia of laparoscopic total hysterectomy can obtain the idea

关 键 词：腹腔镜全子宫切除术 右美托咪定 镇静 镇痛 

分 类 号：R614[医药卫生—麻醉学]