乳酸菌阴道胶囊联合硝呋太尔片治疗对老年细菌性阴道炎患者阴道微环境及复发情况的影响  

Impact of the Combined Treatment of Lactobacillus Vaginal Capsules and Nifuratel Tablets on the Vaginal Microenvironment and Recurrence in Elderly Patients with Bacterial Vaginitis

作　　者：何亮亮 HE Liangliang(Department of Gynecology,Wenshang County Maternal and Child Health Care Family Planning Service Center,Jining 272501,China)

机构地区：[1]汶上县妇幼保健计划生育服务中心妇科,山东济宁272501

出　　处：《反射疗法与康复医学》2024年第23期118-122,共5页Reflexology And Rehabilitation Medicine

摘　　要：目的分析老年细菌性阴道炎患者接受乳酸菌阴道胶囊联合硝呋太尔片治疗的临床疗效。方法选取2022年1月—2024年1月汶上县妇幼保健计划生育服务中心就诊的90例老年细菌性阴道炎患者为研究对象,按随机数字表法将其分为对照组和观察组,每组45例。对照组采用硝呋太尔片治疗,观察组在对照组的基础上采用乳酸菌阴道胶囊治疗,两组均持续14 d。比较两组临床疗效、症状消退时间、阴道微环境、氧化应激指标、复发情况、不良反应发生情况。结果观察组治疗总有效率为95.56%,高于对照组的80.00%,差异有统计学意义(P<0.05)。观察组阴道分泌物异常消退时间、外阴瘙痒消退时间、阴道疼痛消退时间、阴道充血消退时间均短于对照组,组间差异有统计学意义(P<0.05)。治疗前,两组阴道微环境、氧化应激指标比较,组间差异无统计学意义(P>0.05);治疗后,观察组pH值、菌群密集度、内皮素-1、丙二醛水平均低于对照组,超氧化物歧化酶水平高于对照组,组间差异有统计学意义(P<0.05)。随访2个月、5个月后,观察组复发率分别为2.22%、4.44%,均低于对照组的17.78%、22.22%,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论老年细菌性阴道炎患者采用乳酸菌阴道胶囊联合硝呋太尔片治疗,其疗效显著,可缩短临床症状消退时间,改善阴道微环境,缓解氧化应激状态,降低复发率,且具备良好的安全性。Objective Analyze the clinical curative effect of elderly patients with bacterial vaginitis treated with Lactobacillus vaginal capsules combined with Nifuratel tablets.Methods Ninety elderly patients with bacterial vaginitis who visited Wenshang County Maternal and Child Health Care Family Planning Service Center from January 2022 to January 2024 were selected as the research subjects,according to the random number table method,they were divided into a control group and an observation group,with 45 cases in each group.The control group was treated with Nifuratel tablets,and the observation group was treated with Lactobacillus vaginal capsules on the basis of the control group,both groups were treated for 14 consecutive days.The clinical efficacy,symptom regression time,vaginal microenvironment,oxidative stress indicators,recurrence situation and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.56%,which was higher than 80.00%in the control group,and the difference was statistically significant(P<0.05).The regression times of abnormal vaginal discharge,vulvar itching,vaginal pain and vaginal congestion in the observation group were all shorter than those in the control group,and the differences between the groups were statistically significant(P<0.05).Before treatment,the vaginal microenvironment and oxidative stress indicators of the two groups were compared,and the differences between the groups were not statistically significant(P>0.05);after treatment,the pH value,bacterial flora density,levels of endothelin-1 and malondialdehyde in the observation group were all lower than those in the control group,while the level of superoxide dismutase was higher than that in the control group,and the differences between the groups were statistically significant(P<0.05).After 2 months and 5 months of follow-up,the recurrence rates of the observation group were 2.22%,4.44%,which were lower than 17.78%、22.22%of the control gro

关 键 词：细菌性阴道炎 乳酸菌阴道胶囊 硝呋太尔片 临床症状 阴道微环境 

分 类 号：R711.31[医药卫生—妇产科学]