阿奇霉素与红霉素治疗对支原体肺炎患儿临床症状及血清炎症因子水平的影响对比  

Comparison of the Effects of Azithromycin and Erythromycin Treatment on Clinical Symptoms and Serum Inflammatory Factor Levels in Children with Mycoplasma Pneumonia

作　　者：张小敏 ZHANG Xiaomin(Department of Second Pediatrics,Jinxiang County People's Hospital,Jining 272200,China)

机构地区：[1]金乡县人民医院儿二科,山东济宁272200

出　　处：《反射疗法与康复医学》2024年第23期157-160,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的对比阿奇霉素与红霉素治疗对支原体肺炎(MP)患儿临床症状及血清炎症因子水平的影响。方法选择金乡县人民医院2020年8月—2023年8月收治的84例MP患儿为研究对象,按随机数字表法将其分为对照组和观察组,各42例。对照组采用红霉素治疗,观察组采用阿奇霉素治疗。对比两组的临床疗效、临床症状改善情况、血清炎症因子水平及不良反应发生情况。结果观察组治疗总有效率为95.24%,高于对照组的80.95%,差异有统计学意义(P<0.05)。观察组退热、咳嗽消失、肺部啰音消失、喘息消失时间均短于对照组,组间差异有统计学意义(P<0.05)。治疗后,观察组肿瘤坏死因子-α、白细胞介素-4、白细胞介素-6、超敏-C反应蛋白水平均低于对照组,组间差异有统计学意义(P<0.05)。观察组不良反应发生率为4.76%,低于对照组的19.05%,差异有统计学意义(P<0.05)。结论与红霉素相比,阿奇霉素的临床疗效更好,可明显缩短MP患儿的临床症状改善时间,调节血清炎症因子水平,且用药安全性更高。Objective Comparison of the effects of azithromycin and erythromycin treatment on clinical symptoms and serum inflammatory factor levels in children with mycoplasma pneumonia(MP).Methods A total of 84 children with MP admitted to Jinxiang County People's Hospital from August 2020 to August 2023 were selected as the research subjects,according to the random number table method,they were divided into a control group and an observation group,with 42 cases in each group.The control group was treated with erythromycin,while the observation group was treated with azithromycin.Compare the clinical efficacy,improvement of clinical symptoms,serum inflammatory factor levels,and incidence of adverse reactions between two groups.Results The total effective rate of the observation group was 95.24%,which was higher than the 80.95%of the control group,the difference was statistically significant(P<0.05).The time for fever reduction,disappearance of cough,disappearance of lung rales,and disappearance of wheezing in the observation group were shorter than those in the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the levels of tumor necrosis factor-α,interleukin-4,interleukin-6,and high-sensitivity C-reactive protein in the observation group were lower than those in the control group,the differences between the groups were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 4.76%,which was lower than the 19.05%in the control group,the difference was statistically significant(P<0.05).Conclusion Compared with erythromycin,azithromycin has better clinical efficacy,can significantly shorten the time for clinical symptom improvement in children with MP,regulate serum inflammatory factor levels,and has higher medication safety.

关 键 词：支原体肺炎 阿奇霉素 红霉素 临床症状 血清炎症因子水平 

分 类 号：R725.6[医药卫生—儿科]