不同剂量结合型雌激素联合黄体酮在围绝经期综合征患者治疗中的应用效果  

Effect of Different Doses of Conjugated Estrogen Combined with Progesterone in the Treatment of Patients with Perimenopausal Syndrome

作　　者：袁红艳[1] 张丽 沈玉秀[1] YUAN Hongyan;ZHANG Li;SHEN Yuxiu(Department of Pharmacy,Affiliated Hospital of Beihua University,Jilin 132000,China)

机构地区：[1]北华大学附属医院药学部,吉林吉林132000

出　　处：《反射疗法与康复医学》2024年第23期182-185,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的分析不同剂量结合型雌激素(CEE)联合黄体酮在围绝经期综合征(MPS)患者治疗中的应用效果及安全性。方法回顾性选取2023年1月—2024年1月北华大学附属医院收治的82例MPS患者的临床资料,按照接受CEE剂量的不同将其分为标准剂量组和低剂量组,每组41例。标准剂量组采用标准剂量CEE联合黄体酮治疗,低剂量组采用低剂量CEE联合黄体酮治疗,两组均连续治疗3个周期。比较两组患者的临床疗效、病情严重程度、激素指标及不良反应发生情况。结果两组治疗总有效率比较,差异无统计学意义(P>0.05)。治疗3个周期后,两组Kupperman指数(KMI)均低于治疗前,差异有统计学意义(P<0.05),但两组KMI评分比较,差异无统计学意义(P>0.05);两组促卵泡生成素(FSH)、促黄体生成素(LH)均低于治疗前,差异有统计学意义(P<0.05),但两组FSH、LH比较,组间差异无统计学意义(P>0.05);两组雌二醇(E2)均高于治疗前,且标准剂量组高于低剂量组,差异有统计学意义(P<0.05)。低剂量组不良反应发生率为12.20%,低于标准剂量组的31.71%,差异有统计学意义(P<0.05)。结论不同剂量CEE联合黄体酮在治疗MPS上均具有较好疗效,可缓解患者的临床症状,改善激素水平,延缓卵巢功能衰退,其中标准剂量CEE联合黄体酮治疗可进一步改善患者的E2水平,而低剂量CEE联合黄体酮治疗具有更好的安全性。Objective To analyze the efficacy and safety of different doses of conjugated estrogen(CEE)combined with progesterone in the treatment of patients with perimenopausal syndrome(MPS).Methods Clinical data of 82 MPS patients admitted to the Affiliated Hospital of Beihua University from January 2023 to January 2024 were retrospectively selected and divided into a standard dose group and a low dose group according to different CEE doses,with 41 cases in each group.Standard dose group was treated with standard dose CEE combined with progesterone,low dose group was treated with low dose CEE combined with progesterone,and both groups were treated for 3 consecutive cycles.The clinical efficacy,severity of disease,hormone indexes and occurrence of adverse reactions were compared between the two groups.Results There was no significant difference in total effective rate between the two groups(P>0.05).After 3 cycles of treatment,the Kuperman Index(KMI)of the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05),but there was no statistically significant difference in KMI score between the two groups(P>0.05);Follicle-stimulating hormone(FSH)and luteinizing hormone(LH)in two groups were lower than those before treatment,and the difference was statistically significant(P<0.05),but there were no statistically significant differences between two groups in FSH and LH(P>0.05);Estradiol(E2)in both groups were higher than those before treatment,and the standard dose group was higher than that in the low dose group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in low dose group was 12.20%,which was lower than 31.71%in the standard dose group,and the difference was statistically significant(P<0.05).Conclusion Different doses of CEE combined with progesterone have good efficacy in the treatment of MPS,which can alleviate patients'clinical symptoms,improve hormone levels,and delay ovarian function decline.Standard dose CEE combined with progeste

关 键 词：围绝经期综合征 结合型雌激素 黄体酮 临床疗效 不良反应 

分 类 号：R711[医药卫生—妇产科学]