丙型肝炎防治5类重点人群“一站式服务”效果研究  

Effect of"one-stop service"among five categories of high-risk populations in the prevention and treatment of hepatitis C

作　　者：蔡英[1] 李世福[1] 董文斌[1] 杨智彬[2] 李顺祥 朱永芬 罗阳 李泽 杨汝松[1] CAI Ying;LI Shifu;DONG Wenbin;YANG Zhibin;LI Shunxiang;ZHU Yongfen;LUO Yang;LI Ze;YANG Rusong(Division of HIV/AIDS and STD Control,Yuxi Centers for Disease Control and Prevention,Yuxi 653100,Yunnan,China;Department of Infectious Diseases,The People's Hospital of Yuxi,Yuxi 653100,Yunnan,China;Yuxi Emergency Medical Centers,Yuxi 653100,Yunnan,China)

机构地区：[1]玉溪市疾病预防控制中心性病艾滋病控制科,云南玉溪653100 [2]玉溪市人民医院传染病科,云南玉溪653100 [3]玉溪市急救中心,云南玉溪653100

出　　处：《中国艾滋病性病》2025年第1期81-85,共5页Chinese Journal of Aids & STD

基　　金：“兴滇英才计划”名医专项(YNWR-MY-2019-028);玉溪市2023年“兴玉英才支持计划”。

摘　　要：目的探索多部门协同的丙型肝炎(简称丙肝)防治5类重点人群筛查、转介、动员治疗和随访的“一站式服务”及其成效。方法2023年6-12月,玉溪市疾病预防控制中心联合基层丙肝定点治疗机构、民政局等多部门在存活HIV/AIDS患者,HIV/AIDS患者的配偶和性伴,丙肝患者的配偶、性伴及子女,监管场所被监管人员,戒毒所强制戒毒人员等丙肝防治五类重点人群中开展HCV筛查、转介、动员治疗和随访的“一站式服务”,收集调查数据,了解“一站式服务”的成效和治疗成本。结果玉溪市现有丙肝防治五类重点人群11720人,通过“一站式服务”动员HCV抗体筛查11041人(94.21%),HCV抗体阳性率为8.98%(992/11041)。HCV RNA阳性率为52.05%(494/949),接受治疗率77.33%(382/494)。总体治疗完成率97.64%(373/382),治疗完成后12周随访率83.91%(313/373),总体治疗完成后12周获得持续病毒学应答率为98.72%(309/313)。存活HIV/AIDS患者,HIV/AIDS患者的配偶和性伴,丙肝患者的配偶、性伴及子女检测费用(850±118)元,治疗费用(4089±329)元,监管场所被监管人员和戒毒所强制戒毒人员检测费用(861±119)元,治疗费用(12489±569)元。结论多部门协同的“一站式服务”在丙肝防治五类重点人群中高效发现丙肝患者且治疗和随访率均较高,缩短患者等待时间,避免患者流失。Objective To explore the effect of"one-stop service"for the screening,referral,treatment mobilization,and follow-up among five categories of high-risk populations in the prevention and treatment of hepatitis C(HCV)coordinated by multiple departments and its effectiveness.Methods From June to December 2023,the Yuxi Center for Disease Control and Prevention,in conjunction with grassroots HCV-designated treatment institutions,the Civil Affairs Bureau,and other multiple departments,carried out the"one-stop service"for HCV screening,referral,treatment mobilization,and follow-up among five categories of high-risk populations,including the people who lived with HIV;spouses and sexual partners of people who lived with HIV;spouses,sexual partners,and children of patients with HCV;detainees in detention facilities;and compulsory drug addicts in drug rehabilitation centers.Survey data were collected to understand the effectiveness of the"one-stop service"and treatment costs.Results There were 11720 individuals in five categories of high-risk populations for HCV prevention and treatment in Yuxi City.Through the"one-stop service,"11041individuals(94.21%)were mobilized for HCV antibody screening,and the positive rate of HCV antibody was 8.98%(992/11041).The HCV RNA positivity rate was 52.05%(494/949),and the treatment acceptance rate was 77.33%(382/494).The overall treatment completion rate was 97.64%(373/382),and the follow-up and sustained virological response rates at 12 weeks after treatment completion were 83.91%(313/373)and 98.72%(309/313),respectively.The testing and treatment costs for the people who lived with HIV;spouses and sexual partners of people who lived with HIV;and the spouses,sexual partners,and children of HCV patients were 850±118 and 4089±329 yuan,respectively.Moreover,the testing and treatment costs for the detainees in detention facilities and compulsory drug addicts in drug rehabilitation centers were 861±119 and 12489±569 yuan,respectively.Conclusions The"one-stop service"coordinated by multiple d

关 键 词：丙型肝炎 筛查 转介 治疗 随访 

分 类 号：R512.91[医药卫生—内科学]