IFN-β在病毒感染中的作用研究进展  

Research progress on the role of IFN-βin viral infection

作　　者：邵帅 纪晓岚[1,2,3,4] 范益阳 柏家林 李琼毅[1,3,4] SHAO Shuai;JI Xiaolan;FAN Yiyang;BAI Jialin;LI Qiongyi(Life Science and Engineering College of Northwest Minzu University,Lanzhou 730030,China;Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,China;Engineering Research Centre of Ministry of Education for Key Technology and Industrialisation of Acellular Matrix Vaccine,Northwest Minzu University,Lanzhou 730030,China;Gansu Tech Innovation Center of Animal Cell,Lanzhou 730030,China)

机构地区：[1]西北民族大学生命科学与工程学院,兰州730030 [2]西北民族大学生物医学研究中心生物工程与技术国家民委重点实验室,兰州730030 [3]西北民族大学细胞基质疫苗关键技术与产业化教育部工程研究中心 [4]甘肃省动物细胞技术创新中心,兰州730030

出　　处：《免疫学杂志》2024年第11期844-855,共12页Immunological Journal

基　　金：甘肃省自然科学基金(23JRRA720)。

摘　　要：IFN-β由成纤维细胞、白细胞、上皮细胞等多种细胞分泌,在固有免疫应答中发挥重要作用,通过激活一系列抗病毒基因的表达,增强宿主的免疫应答。具有抑制病毒复制、抗寄生虫、影响细胞增殖、参与免疫调节、抗肿瘤等多种生物功能。本文主要综述了DNA病毒和RNA病毒感染后IFN-β的激活及其抗病毒作用和部分病毒进化出的免疫逃逸机制,总结了病毒感染调控干扰素信号通路研究进展,为今后抗病毒感染机制研究及其防治提供参考。IFN-β,secreted by fibroblasts,leukocytes,epithelial cells and other cells,plays an important role in the intrinsic immune response,and involves in the body's anti-viral immune response by inducing a variety of antiviral genes.It has various biological functions such as inhibiting viral replication,anti-parasite,influencing cell proliferation,participating in immune regulation,and anti-tumor.This paper mainly reviews the activation of IFN-βand its antiviral effects after DNA virus and RNA virus infections and the immune escape mechanism evolved by some viruses,and summarizes the progress of the research on the interferon signaling pathway regulated by viral infections,so as to provide references for the future research on the mechanism of antiviral infections and their prevention and treatment.

关 键 词：干扰素 IFN-Β 抗病毒 感染 

分 类 号：S855.3[农业科学—临床兽医学]