纳米药物治疗鸡球虫病的研究进展  

Research progress on nanomedicine for treating chicken coccidiosis

作　　者：范玉青 彭树德 白和平 史秋梅[4] FAN Yuqing;PENG Shude;BAI Heping;SHI Qiumei(Zhao County Comprehensive Vocational and Technical Education Center,ZhaoCounty,Hebei 051530,China;Tangshan Food and Drug Comprehensive Inspection and Testing Center,Tangshan,Hebei 063000,China;College of Traditional Chinese Veterinary Medicine,Hebei Agricultural University,Baoding,Hebei 071000,China;Hebei Key Laboratory of Preventive Veterinary Medicine,Hebei Normal University of Science and Technology,Qinhuangdao,Hebei 066004,China)

机构地区：[1]赵县综合职业技术教育中心,河北赵县051530 [2]唐山市食品药品综合检验检测中心,河北唐山063000 [3]河北农业大学中兽医学院,河北保定071000 [4]河北科技师范学院,河北省预防兽医学重点实验室,河北秦皇岛066004

出　　处：《中国兽医学报》2024年第11期2490-2495,共6页Chinese Journal of Veterinary Science

基　　金：河北省肉鸡养殖与加工技术创新中心科研资助项目

摘　　要：鸡球虫专门在鸡肠道黏膜上皮细胞内生长繁殖,危害鸡群健康。然而,传统的化学药物很难通过细胞屏障,并且易造成耐药虫株的出现以及兽药残留问题,给球虫病的防控带来巨大的挑战,因此,有必要开发新的抗球虫策略。纳米药物具有生物相容性好、易修饰且效率高等优势,提高细胞膜的穿透性的同时降低了药物的毒副作用,有望应用于球虫病防治。本文介绍了多种抗鸡球虫病的纳米药物,总结了其与传统制剂相比的优点,重点介绍纳米药物在治疗鸡球虫病中的应用,阐述目前纳米药物治疗鸡球虫病仍存在的问题,并对该领域面临的挑战和未来发展方向进行展望,以期为开发用于治疗鸡球虫病的纳米药物提供重要参考。Chicken coccidia specialize in growing and reproducing within the epithelial cells of the chicken intestinal mucosa,posing a threat to the health of the chicken flock.However,traditional chemical drugs are difficult to pass through the cell barrier and can easily lead to the emergence of drug-resistant strains and residual veterinary drugs,posing a huge challenge to the prevention and control of coccidiosis.Therefore,it is necessary to develop new strategies against coccidiosis.Nanodrugs have the advantages of good biocompatibility,easy modification,and high efficiency,improving the penetration of cell membranes while reducing drug toxicity and side effects.They are expected to be applied in the prevention and treatment of coccidiosis.This article introduces various nanomedicines for treating chicken coccidiosis,summarizes their advantages compared to traditional formulations,focuses on the application of nanomedicines in the treatment of chicken coccidiosis,elucidates the existing problems of nanomedicine treatment for chicken coccidiosis,and looks forward to the challenges and future development directions in this field,in order to provide important references for the development of nanomedicines for treating chicken coccidiosis.

关 键 词：鸡 球虫病 纳米药物 球虫病防治 

分 类 号：S853.7[农业科学—临床兽医学]