膳食炎症指数水平与妇科恶性肿瘤风险的相关性  

The correlation between dietary inflammation index levels and the risk of gynecologic malignancies

作　　者：张峰莉 王中显 冉薇 冯小希 莫春艳 ZHANG Fengli;WANG Zhongxian;RAN Wei;FENG Xiaoxi;MO Chunyan(Department of Obstetrics and Gynecology,the Third People′s Hospital of Hubei Province,Wuhan 430033,Hubei,China)

机构地区：[1]湖北省第三人民医院妇产科,湖北武汉430033

出　　处：《暨南大学学报(自然科学与医学版)》2025年第1期43-52,共10页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：湖北省卫生健康委科研项目(WJ2021F144)。

摘　　要：目的:探讨膳食炎症指数(dietary inflammatory index,DII)水平与妇科恶性肿瘤风险的相关性。方法:选取2021年1月至2022年3月在湖北省第三人民医院确诊为妇科恶性肿瘤的52例患者为病例组,同期体检的315例健康者为对照组。通过填写个人史问卷和食物频率问卷(FFQ25)收集一般人口学资料及膳食摄入情况,依据中国食物成分表(2002版)计算膳食成分含量,计算个人DII值,运用倾向性评分匹配(propensity score matching,PSM)的方法使队列的基线资料相似,Logistic回归评估DII值与妇科恶性肿瘤风险的相关性。调阅研究对象体检报告,分析炎症指标包括中性粒细胞、淋巴细胞、血小板、中性粒细胞-淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)、血小板-淋巴细胞比值(platelet-lymphocyte ratio,PLR)、C反应蛋白(C-reactive protein,CPR)水平。结果:运用多元回归方程分析,未调整混杂变量、调整Ⅰ及调整Ⅱ方案均显示DII值、DII高分值(0.62~4.82)与妇科恶性肿瘤的发生密切相关,差异有统计学意义(P<0.01),同时进行敏感性分析,与未进行PSM前比较,结论一致。运用平滑曲线拟合发现,DII值与妇科恶性肿瘤的发生呈曲线关系;通过阈值分析发现,DII值拐点为1,差异有统计学意义(P<0.01)。病例组炎症指标(NLR、PLR、CPR)水平均高于对照组,差异有统计学意义(P<0.01)。根据阈值分析,将DII分成2组,DII≥1组炎症指标水平均高于DII<1组,差异有统计学意义(P<0.01)。结论:DII值与妇科恶性肿瘤的发生呈曲线关系;DII值可用于预测妇科恶性肿瘤风险,当DII值大于1时,需要高度警惕妇科恶性肿瘤的发生发展。可利用DII值指导居民膳食结构和进行相关营养教育,以预防妇科恶性肿瘤的发生发展。Objective:To explore the relationship between dietary inflammation index and the risk of gynecologic malignant tumor.Methods:From January 2001 to March 2022,52 patients with gynecological malignant tumors were selected as case group,and 315 healthy persons were selected as control group.By filling in personal history questionnaire and food frequency questionnaire(FFQ25)to collect general demographic data and dietary intake,the dietary composition was calculated according to Chinese food composition table(2002 Edition),and personal DII values were ultimately calculated.Propensity score matching(PSM)was used to make the baseline data of the cohort similar,and Logistic regression was used to assess the association between DII values and the risk of gynecologic malignancy.To consult the medical examination reports of the two groups,inflammatory markers including neutrophil,lymphocyte,platelets,neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and C-reactive protein(CPR)were analyzed.Results:By using multiple regression equation,the scheme of unadjusted confounding variables,scheme of adjustedⅠand scheme of AdjustedⅡshowed that the DII value and the high DII score(0.62-4.82)were closely related to the occurrence of gynecological tumors,the difference was significant(P<0.01),and the results of sensitivity analysis were consistent with those before propensity score matching.The relationship between DII value and the occurrence of gynaecological tumors was found by smoothing curve fitting;through threshold analysis,it was found that the inflection point of DII value was 1,and the difference was statistically significant(P<0.01).The levels of inflammatory markers such as NLR,PLR and CPR in the case group were higher than those in the control group,the difference was statistically significant(P<0.01).According to threshold analysis,DII was divided into two groups,the levels of inflammatory markers in DII≥1 group were significantly higher than those in DII<1 group(P<0.01).Conclusion:DII value has a

关 键 词：膳食炎症指数 妇科恶性肿瘤 炎症 倾向性评分匹配 

分 类 号：R271.1[医药卫生—中医妇科学]