3D打印技术在血管再生领域的应用  

Application of 3D printing technology in the field of vascular regeneration

作　　者：倪忞 曹霞[1] 徐希明[1] 余江南[1] NI Min;CAO Xia;XU Ximing;YU Jiangnan(School of Pharmacy,Jiangsu University,Zhenjiang 212013,Jiangsu,China)

机构地区：[1]江苏大学药学院,江苏镇江212013

出　　处：《暨南大学学报(自然科学与医学版)》2025年第1期117-126,共10页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：国家自然科学基金项目(82173785)。

摘　　要：3D打印技术在生物医学领域的迅速发展为血管再生提供了新的解决方案。本文综述了3D打印技术在血管再生中的应用,重点讨论了其在生物材料设计、血管结构构建和细胞载体开发等方面的创新进展,详细介绍了常见血管支架材料的特点、生物活性因子的释放系统和仿真模型的建立等。通过分析打印技术、生物材料和活性因子等在实际应用中对血管再生的影响,探讨了如何进一步利用3D打印技术精确构建具有生物相容性的血管组织模型。同时,提出了生物相容性材料的选择、打印的精度、细胞存活率与功能保持等未来发展方向。3D打印技术在血管再生领域具有广阔的前景,但仍需克服生物相容性和功能性等挑战,以实现更广泛的临床应用。Rapid advancements of 3D printing technology in the biomedical field have provided new solutions for vascular regeneration.This paper summarized applications of 3D printing in vascular regeneration,highlighting innovations in biomaterial design,vascular structure construction and cell carrier development.It details the characteristics of common vascular scaffold materials,the release systems of bioactive factors,and the establishment of simulation models.By analyzing the impacts of printing technology,biomaterials and active factors on vascular regeneration in practical applications,this paper discussed how to further utilize 3D printing technology to accurately build biocompatible vascular tissue models.Additionally,it addressed future directions including the selection of biocompatible materials,printing precision,cell survival rate,and maintenance of function.3D printing technology has broad prospect in the field of vascular regeneration,but challenges in biocompatibility and functionality must be overcome for broad clinical application.

关 键 词：3D打印 血管再生 组织工程 血管结构 生物墨水 

分 类 号：R318.1[医药卫生—生物医学工程]