FeNO检测在学龄期儿童支气管哮喘严重度及治疗评估中的应用  

Application of FeNO measurement in the assessment of severity and treatment of bronchial asthma in school-aged children

作　　者：王娟 WANG Juan(Department of Pediatrics,Danyang Maternal and Child Health Hospital,Danyang,Jiangsu,212300,China)

机构地区：[1]丹阳市妇幼保健院儿科,江苏丹阳212300

出　　处：《中国冶金工业医学杂志》2025年第1期4-6,共3页Chinese Medical Journal of Metallurgical industry

基　　金：丹阳市科技项目(2022AD41000009)。

摘　　要：目的 探讨呼出一氧化氮(FeNO)检测在学龄期儿童支气管哮喘评估及治疗中的应用效果。方法 选取2021—2022年丹阳市妇幼保健院收治的80例学龄期支气管哮喘患儿作为实验组,另选取同期体检的70例健康体检儿童作为对照组。检测两组治疗前和治疗3个月后的FeNO、第1秒用力呼吸容积占肺活量比值(FEV_(1)%)、免疫球蛋白E(IgE)指标水平;分析实验组患儿FeNO与FEV_(1)%、IgE的相关性。结果 实验组治疗前FeNO、IgE水平明显高于对照组,FEV_(1)%低于对照组,两组比较差异均有统计学意义(t=29.733、15.436、28.832,均P<0.05);治疗后,实验组FeNO、IgE水平虽低于治疗前,但仍高于对照组,两组比较差异均有统计学意义(t=17.881、26.690,均P<0.05);治疗后,实验组FEV_(1)%水平虽高于治疗前,但仍低于对照组,两组比较差异无统计学意义(t=0.698,P>0.05);实验组不同严重程度患儿治疗前后的FeNO水平比较,差异均有统计学意义(F=6.200、3.259,均P<0.05);治疗前,实验组轻、中、重度患儿的FeNO与IgE水平呈正相关(r=0.427,P=0.009),与FEV_(1)%呈负相关性(r=-0.389,P=0.008);治疗后,实验组轻、中、重度患儿的FeNO与IgE水平呈正相关(r=0.378,P=0.014),与FEV_(1)%无相关性(r=-0.105,P=0.023)。结论 学龄期儿童支气管哮喘FeNO水平高于健康儿童,FeNO与FEV_(1)%、血清IgE有显著相关性,FeNO检测有助于患儿病情严重程度的评估,对临床具有参考价值。Objective To investigate the application of Fe NO test in the assessment and treatment of bronchial asthma in school-age children.Methods A total of 80 school-age children with bronchial asthma admitted to Danyang maternal and child health hospital from 2021 to 2022 were included in the study as the experimental group,and 70 healthy children with undergoing physical examination during the same period were included as the control group.The levels of FeNO,forced expiratory volume in one second to vital capacity ratio(FEV_(1)%) and immunoglobulin E(IgE) were detected before treatment and 3 months after treatment in the two groups.The correlation of FeNO with FEV_(1)% and IgE in the experimental group was analyzed.Results Before treatment,the FeNO and IgE levels in the experimental group were significantly higher than those in the control group,while the FEV_(1)% was significantly lower.These differences were statistically significant(t=29.733,15.436,28.832;all P<0.05).After treatment,FeNO and IgE levels in the experimental group decreased but remained higher than those in the control group.These differences were statistically significant(t=17.881,26.690;all P<0.05).Although the FEV_(1)% level of the experimental group after treatment was higher than that before treatment,it was still lower than that of the control group.There was no significant difference between the two groups(t=0.698,P>0.05).FeNO levels varied significantly among patients with different severity levels before and after treatment(F=6.200,3.259;both P<0.05).Before treatment,FeNO was positively correlated with IgE levels(r=0.427,P=0.009) and negatively correlated with FEV_(1)%(r=-0.389,P=0.008) in mild,moderate,and severe patients in the experimental group.After treatment,FeNO was positively correlated with IgE levels(r=0.378,P=0.014) but not correlated with FEV_(1)%(r=-0.105,P=0.023).Conclusion FeNO levels in school-age children with bronchial asthma are higher than in healthy children.FeNO is significantly correlated with FEV_(1)% and serum IgE lev

关 键 词：FeNO检测 学龄期儿童支气管哮喘 免疫球蛋白E 肺功能 相关性 

分 类 号：R562.25[医药卫生—呼吸系统]