山茱萸的现代药理作用及机制研究进展  

Research progress on modern pharmacological action and mechanism of Cornus officinalis

作　　者：陈倩[1] 张馨月 刘俊伶 贾楠 王飞[1] CHEN Qian;ZHANG Xinyue;LIU Junling;JIA Nan;WANG Fei(Department of Geriatrics,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China)

机构地区：[1]成都中医药大学附属医院老年病科,610072

出　　处：《环球中医药》2025年第2期388-396,共9页Global Traditional Chinese Medicine

基　　金：国家重点研发计划(2020YFC2003104)。

摘　　要：山茱萸是山茱萸科山茱萸属植物,为国药大宗品种之一,中医理论认为其功擅补益肝肾、涩精固脱。目前从山茱萸中已提取鉴定出包括环烯醚萜苷类、鞣质类、三萜类、黄酮类等200余种活性成分。本文从山茱萸的药效成分和分子信号通路等方面切入,对山茱萸的现代药理作用及机制研究进展进行归纳和总结。实验研究表明,山茱萸提取物及其活性成分具有抗衰老、抗氧化、保护神经系统、保护心血管系统、保肝护肾、调节免疫、抗肿瘤、调节糖脂代谢、抗骨质疏松、抑菌、抗炎等多种药理作用,但其临床研究仍在进行中。本文提出展望,旨在为山茱萸的进一步研究以及临床应用提供参考。Cornus officinalis is a genus of cornus officinalis in the Cornel family,one of the major varieties of Chinese herbal medicine,which is good at nourishing liver and kidney,astringing essence and securing collapse according to the theory of traditional Chinese medicine.At present,more than 200 active components including iridoid glycosides,tannins,triterpenoids,and flavonoids have been extracted and identified from Cornus officinali s.This article reviewed the research progress of modern pharmacological action and mechanism of Cornus officinalis from the aspects of pharmacodynamic components and molecular signaling pathways.Experimental studies have shown that the extract of Cornus officinalis and its active ingredients have a variety of pharmacological functions such as anti-aging,anti-oxidation,protection of nervous system,protection of cardiovascular system,protection of liver and kidney,regulation of immunity,anti-tumor,regulation of glucose and lipid metabolism,anti-osteoporosis,anti-bacterial,and anti-inflammation.However,its clinical research is still in progress.This article provided references for its further research and clinical application.

关 键 词：山茱萸 药理作用 药效机制 研究进展 综述 

分 类 号：R285[医药卫生—中药学]