子宫内膜异位症患者血清VIP、Ang-2、nesfatin-1水平变化及其与病情的关系  

Changes of serum VIP,Ang-2 and nesfatin-1 in patients with endometriosis and relationship with disease conditions

作　　者：任宝花 郭静 王闯 REN Bao-hua;GUO Jing;WANG Chuang(Department of Obstetrics and Gynecology,Hegang People's Hospital,Hegang 154101,Heilongjiang,China)

机构地区：[1]鹤岗市人民医院妇产科,黑龙江鹤岗154101

出　　处：《川北医学院学报》2025年第2期164-167,176,共5页Journal of North Sichuan Medical College

基　　金：黑龙江省自然科学基金资助项目(D96)。

摘　　要：目的:探究子宫内膜异位症(EMS)患者血清血管活性肠肽(VIP)、血管生成素-2(Ang-2)、摄食抑制因子-1(nesfatin-1)水平变化及其与病情的关系。方法:纳入115例经腹腔镜手术治疗后病理证实为EMS的患者作为EMS组,根据患者疾病分期不同分为初期组(n=41,分期为Ⅰ~Ⅱ期)和晚期组(n=74,分期为Ⅲ~Ⅳ期);纳入同期60名健康体检女性志愿者作为健康组,对比EMS组与健康组一般资料与临床指标;对比初期组与晚期组血清指标;采用Pearson法分析血清指标与临床指标相关性。随访1年,EMS组患者依据结局分为妊娠组(n=68)与未妊娠组(n=47),对比两组血清指标;采用ROC曲线分析血清指标评估预后的临床价值。结果:EMS组流产史、糖类抗原125(CA125)均高于健康组(P<0.05),雌二醇(E_(2))、孕酮(P)、卵泡刺激素(FSH)均低于健康组(P<0.05);EMS组血清指标均高于健康组(P<0.05);晚期组血清指标均高于初期组(P<0.05);血清指标与CA125正相关(P<0.05),与E_(2)、P、FSH负相关(P<0.05);未妊娠组血清指标均高于妊娠组(P<0.05);三项血清指标的曲线下面积(AUC)分别为0.650、0.701、0.727,三项联合诊断AUC为0.798,联合诊断价值更高。结论:血清VIP、Ang-2、nesfatin-1水平与EMS发病及进展关系密切,可作为临床诊断参考指标,联合诊断价值更高。Objective:To investigate the changes of serum vasoactive intestinal peptide(VIP),angiopoietin-2(Ang-2)and nesfatin-1 in patients with endometriosis(EMS)and the relationship with disease conditions.Methods:A total of 115 patients with EMS confirmed by postoperative pathology after laparoscopic surgery were included in EMS group.According to the different stages of disease,the patients were divided into early group(n=41,stageⅠ~Ⅱ)and late group(n=74,stageⅢ~Ⅳ).60 healthy women with physical examination were enrolled as healthy group.Baseline data and clinical indicators between EMS group and healthy group and serum indicators between early group and late group were compared.Pearson method was used to analyze the correlation between serum indicators and clinical indicators.After 1 year of follow-up,the patients in EMS group were classified into pregnancy group(n=68)and non-pregnancy group(n=47)by means of outcomes,and serum indicators were compared.The clinical value of serum indicators on evaluating prognosis was analyzed by ROC curve.Results:Abortion history and CA125 in EMS group were higher than those in healthy group(P<0.05),E2,P and FSH were lower than those in healthy group(P<0.05).The levels of serum indicators were higher in EMS group than those in healthy group(P<0.05),and were higher in late group than those in early group(P<0.05).Serum indicators were positively correlated with CA125(P<0.05),and were negatively correlated with E2,P and FSH(P<0.05).Serum indicators levels in non-pregnancy group were higher than those in pregnancy group(P<0.05).The AUCs of three serum indicators were 0.650,0.701 and 0.727 respectively,and the AUC of the combination of the three was 0.798,indicating a higher value of combined diagnosis.Conclusion:Serum VIP,Ang-2 and nesfatin-1 levels are closely related to the pathogenesis and progression of EMS,which can be used as reference indicators for clinical diagnosis,and combined diagnosis has higher value.

关 键 词：子宫内膜异位症 血管活性肠肽 血管生成素-2 摄食抑制因子-1 

分 类 号：R446.11[医药卫生—诊断学] R711.71[医药卫生—临床医学]