双歧杆菌四联活菌联合微量喂养治疗早产儿喂养不耐受的疗效及其对胃肠功能和血浆ghrelin、CCK水平的影响  

Efficacy of bifidobacterium quadruple viable bacteria combined with micro-feeding on feeding intolerance in premature infants and its influence on gastrointestinal function and plasma ghrelin and CCK levels

作　　者：毛妍 薛莉莎 殷得莉 MAO Yan;XUE Li-sha;YIN De-li(Department of Neonatology,Shiyan Taihe Hospital,Affiliated Hospital of Hubei University of Medicine,Shiyan 442000,Hubei,China)

机构地区：[1]十堰市太和医院·湖北医药学院附属医院新生儿科,湖北十堰442000

出　　处：《川北医学院学报》2025年第2期187-190,共4页Journal of North Sichuan Medical College

基　　金：湖北省自然科学基金项目(2015CBD03174)。

摘　　要：目的:探究双歧杆菌四联活菌联合微量喂养治疗早产儿喂养不耐受的疗效及其对胃肠功能和血浆胃饥饿素(ghrelin)、胆囊收缩素(CCK)水平的影响。方法:纳入120例喂养不耐受早产儿为研究对象,按照干预方式不同将其分为喂养组(n=60,采用微量喂养治疗)和活菌组(n=60,采用双歧杆菌四联活菌联合微量喂养治疗)。对比两组患儿临床疗效、恢复情况(恢复喂养耐受时间、达到正常体质量时间、腹胀消失时间、呕吐消失时间)、治疗前后胃肠功能(胃动素、ghrelin、CCK)、肝功能[白蛋白、总胆红素(TBIL)]及不良事件发生率。结果:活菌组疗效总有效率(96.67%)高于喂养组(86.67%)(P<0.05);活菌组各项恢复时间均低于喂养组(P<0.05);治疗后,两组患儿胃动素、ghrelin、白蛋白水平均上升(P<0.05),CCK、TBIL水平均下降(P<0.05),且活菌组胃动素、ghrelin、白蛋白均高于喂养组(P<0.05),CCK、TBIL水平均低于喂养组(P<0.05);活菌组不良事件总发生率(3.33%)低于喂养组(15.00%)(P<0.05)。结论:双歧杆菌四联活菌联合微量喂养可有效治疗早产儿喂养不耐受,改善胃肠功能,降低不良事件发生率,值得临床推广应用。Objective:To explore the efficacy of bifidobacterium quadruple viable bacteria combined with micro-feeding in the treatment of feeding intolerance in premature infants and its influence on gastrointestinal function and plasma ghrelin and cholecystokinin(CCK)levels.Methods:A total of 120 premature infants with feeding intolerance were included,and were divided into feeding group(n=60,micro-feeding therapy)and viable bacteria group(n=60,bifidobacterium quadruple viable bacteria combined with micro-feeding therapy)by different intervention methods.The clinical efficacy,recovery status(feeding tolerance recovery time,normal body mass recovery time,abdominal distension disappearance time,vomiting disappearance time),gastrointestinal function(motilin,ghrelin,CCK)and liver function[albumin,total bilirubin(TBIL)]before and after treatment and incidence rates of adverse events were compared between the two groups.Results:The total efficacy in viable bacteria group was higher than that in feeding group(96.67%vs.86.67%,P<0.05).The recovery time of each item was shorter in viable bacteria group than that in feeding group(P<0.05).After treatment,the levels of motilin,ghrelin and albumin in the two groups were increased(P<0.05)while the levels of CCK and TBIL were decreased(P<0.05).The motilin,ghrelin and albumin levels in viable bacteria group were higher in viable bacteria group(P<0.05),the levels of CCK and TBIL were lower compared to feeding group(P<0.05).The total incidence rate of adverse events in viable bacteria group was lower than that in feeding group(3.33%vs.15.00%,P<0.05).Conclusion:Bifidobacterium quadruple viable bacteria combined with micro-feeding can effectively treat feeding intolerance in premature infants,improve gastrointestinal function and reduce the incidence rates of adverse events.It is worthy of clinical promotion and application.

关 键 词：早产儿 喂养不耐受 双歧杆菌四联活菌 微量喂养 胃肠功能 

分 类 号：R722[医药卫生—儿科]