常规脑电图结合事件相关电位P300在注意缺陷和多动障碍患者中的特点及其临床应用  

The characteristics and clinical application of routine electroencephalogram combined with event-related potential P300 in patients with attention deficit and hyperactivity disorder

作　　者：林红 黄静 邹雪萍 李宗磊 LIN Hong;HUANG Jing;ZOU Xue-ping;LI Zong-lei(Brain Function Examination Room,Xiamen Xianyue Hospital,Xiamen 361012,Fujian,China;Department of Child and Adolescent Psychology,Xiamen Xianyue Hospital,Xiamen 361012,Fujian,China)

机构地区：[1]厦门市仙岳医院脑功能检查室,福建厦门361012 [2]厦门市仙岳医院儿童青少年心理科,福建厦门361012

出　　处：《川北医学院学报》2025年第2期195-199,共5页Journal of North Sichuan Medical College

基　　金：福建省卫生健康青年科研项目(2019-2-54)。

摘　　要：目的:分析常规脑电图结合事件相关电位P300在注意缺陷和多动障碍患者中的特点及临床应用。方法:选取注意缺陷患者为注意缺陷组(n=50);多动障碍患者为多动障碍组(n=50);另选取健康体检者为对照组(n=50)。比较各组患者一般资料及常规脑电图、事件相关电位P300检查,获取Pz、Cz、Fz潜伏期、波幅、δ波、θ波、α波波幅及频率、脑电图异常情况。结果:各组对象性别、年龄、身体质量指数、文化水平、营养不良状况比较,差异无统计学意义(P>0.05);与对照组相比,注意缺陷组、多动障碍组患者有脑外伤史占比较高,MoCA评分较低(P<0.05);注意缺陷组、多动障碍组脑外伤史、MoCA评分均无统计学差异(P>0.05)。与对照组相比,注意缺陷组、多动障碍组患者Pz、Cz、Fz潜伏期水平均较高,波幅水平均较低,脑电图异常率较高,δ波、θ波、α波波幅水平均较高(P<0.05);注意缺陷组、多动障碍组患者Pz、Cz、Fz潜伏期及波幅、δ波、θ波、α波波幅水平、脑电图异常率无统计学差异(P>0.05);各组δ波、θ波、α波频率水平对比无统计学差异(P>0.05)。ROC曲线显示,与事件相关电位P300、常规脑电图单项诊断相比,联合检测诊断注意缺陷、多动障碍的敏感性、准确性较高(P<0.001)。结论:注意缺陷和多动障碍患者Pz、Cz、Fz潜伏期、脑电图异常率、δ波、θ波、α波波幅水平较高,Pz、Cz、Fz波幅水平较低,常规脑电图结合事件相关电位P300对注意缺陷和多动障碍的诊断价值较高。Objective:To analyse the characteristics and clinical application of routine electroencephalogram combined with event-related potential P300 in patients with attention deficit and hyperactivity disorder.Methods:Selected 50 patients with attention deficit as the attention deficit group,50 patients with hyperactivity disorder as the hyperactivity disorder group,and another 50 healthy individuals for physical examination as the control group.All patients in each group underwent general data statistics and routine EEG and event-related potential P300 examinations to obtain the latency,amplitude,δwave,θwave,αwave amplitude and frequency of Pz,Cz,and Fz,as well as abnormal EEG conditions.Results:There were no significant differences in gender,age,body mass index,educational level,and malnutrition among the three groups(P>0.05).Compared with the control group,the attention deficit group and hyperactivity disorder group had a higher proportion of patients with a history of traumatic brain injury and lower MoCA scores(P<0.05).There was no significant difference in the history of traumatic brain injury and MoCA score between the attention deficit group and the hyperactivity disorder group(P>0.05).Compared with the control group,patients with attention deficit and hyperactivity disorder had higher levels of latent periods of Pz,Cz,and Fz,lower levels of wave amplitudes,higher rates of EEG abnormalities,and higher levels of amplitude ofδ,θ,andαwaves(P<0.05).There was no significant difference in the latency and amplitude of Pz,Cz,and Fz,as well as the amplitude levels ofδ,θ,andαwaves,and the proportion of abnormal EEG between the attention deficit group and the hyperactivity disorder group(P>0.05).There was no significant difference in the frequency levels of the three groups ofδwave,θwave,andαwave(P>0.05).The ROC curve showed that compared with the single diagnosis of event-related potential P300 and conventional electroencephalogram,the combined detection had higher sensitivity and accuracy in diagnosing attent

关 键 词：常规脑电图 事件相关电位P300 潜伏期 注意缺陷 多动障碍 诊断价值 

分 类 号：R725[医药卫生—儿科] R749.94[医药卫生—临床医学]