非对称性二甲基精氨酸与活性氧在内皮功能障碍中的作用机制研究进展  

Role and Mechanism of Asymmetric Dimethylarginine and Reactive Oxygen Species in Endothelial Dysfunction

作　　者：俞成云 芦秀燕 张铭 杜招娜 夏伟[2] YU Chengyun;LU Xiuyan;ZHANG Ming;DU Zhaona;XIA Wei(School of Clinical Medicine,Shandong Second Medical University,Weifang 261053,Shandong,China;Department of Cardiology,East Hospital of Qingdao Municipal Hospital,Qingdao Hospital of Rehabilitation University,Qingdao 266000,Shandong,China)

机构地区：[1]山东第二医科大学临床医学院,山东潍坊261053 [2]康复大学青岛医院青岛市市立医院东院区心内科,山东青岛266000

出　　处：《心血管病学进展》2025年第2期153-157,共5页Advances in Cardiovascular Diseases

基　　金：青岛市医药卫生科研指导项目(2023-WJZD157)。

摘　　要：内皮功能障碍是心血管疾病的早期特征,通常被定义为一氧化氮生物利用度降低。非对称性二甲基精氨酸作为一氧化氮合成的天然抑制剂,其血浆浓度升高近些年一直被视为内皮功能障碍的独立危险因素。生理状况下,活性氧与一氧化氮保持合成平衡,共同参与内皮屏障维护,其平衡破坏介导的内皮功能障碍是多种心血管疾病发生发展的病理生理机制之一。现主要对非对称性二甲基精氨酸与活性氧在内皮功能障碍中的作用机制及争议进行综述,以期为心血管疾病的预防和治疗提供新思路。Endothelial dysfunction is an early feature of cardiovascular disease and is often defined as reduced nitric oxide bioavailability.Asymmetric dimethylarginine is a natural inhibitor of nitric oxide synthesis,and its elevated plasma concentration has been implicated as an independent risk factor for endothelial dysfunction in recent years.At physiological conditions,reactive oxygen species and nitric oxide maintain a synthetic balance and participate in the maintenance of endothelial barrier,when their balanc is destroyed,it can directly lead to endothelial dysfunction,which is one of the pathophysiological mechanisms of the occurrence and progression of various cardiovascular diseases.In this article,we mainly review the mechanism and controversy of asymmetric dimethylarginine and reactive oxygen species in endothelial dysfunction.In order to provide new ideas for the prevention and treatment of cardiovascular diseases.

关 键 词：内皮功能障碍 一氧化氮 非对称性二甲基精氨酸 活性氧 

分 类 号：R54[医药卫生—心血管疾病]