急性高甘油三酯血症胰腺炎患者血清IL-17、NF-κB水平与病情进展的关系  

Relationship between serum levels of interleukin-17(IL-17),nuclear factor-κB(NF-κB)and disease progression in patients with acute hypertriglyceridemic pancreatitis(HTG-AP)

作　　者：谭菊容 黄竹英 易岑[2] 庄建云 TAN Jurong;HUANG Zhuying;YI Cen;ZHUANG Jianyun(Department of Clinical Laboratory,Changsha Traditional Chinese Medicine Hospital,Changsha 410100,China;Department of Clinical Laboratory,Wuhan First Hospital,Wuhan 430022,China)

机构地区：[1]长沙市中医医院/长沙市第八医院检验科,长沙410100 [2]武汉市第一医院检验科,武汉430022

出　　处：《新疆医科大学学报》2025年第2期156-161,169,共7页Journal of Xinjiang Medical University

基　　金：2024年度医药卫生行业联合基金项目(2024JJ9529)。

摘　　要：目的探讨急性高甘油三酯血症胰腺炎(HTG-AP)患者血清白细胞介素-17(IL-17)、核因子-κB(NF-κB)水平与病情进展的关系。方法选取2021年10月-2024年8月长沙市中医医院(长沙市第八医院)HTG-AP患者142例,均检测血清IL-17、NF-κB水平和统计HTG-AP患者病情进展情况,分析HTG-AP患者病情进展的影响因素及IL-17、NF-κB与HTG-AP患者病情进展的关系。结果142例HTG-AP患者中有41例进展为SAP,发生率为28.87%(41/142),纳入SAP组,其余101例中MAP 56例,MSAP 45例,纳入NSAP组。SAP患者血清IL-17、NF-κB水平高于MSAP和MAP患者,MSAP患者IL-17、NF-κB水平高于MAP患者(P<0.05)。SAP组患者血清IL-17、NF-κB水平高于NSAP组患者(P<0.05)。血清IL-17、NF-κB水平与HTG-AP患者病情程度呈正相关(P<0.05)。血清IL-17、NF-κB水平联合预测HTG-AP患者病情进展的曲线下面积(AUC)值大于单一指标的预测值(P<0.05)。结论无论是否调整混杂因素,血清IL-17、NF-κB水平升高均会增加HTG-AP患者病情进展风险。血清IL-17、NF-κB有望作为预测患者病情进展情况的潜在指标。Objective To investigate the relationship between serum levels of interleukin-17(IL-17),nuclear factor-κB(NF-κB)and disease progression in patients with acute hypertriglyceridemic pancreatitis(HTG-AP).Methods A total of 142 patients with HTG-AP in the hospital from October 2021 to August 2024 were selected,and serum levels of IL-17 and NF-κB were detected.The influencing factors of disease progression in HTG-AP patients and the relationship between IL-17,NF-κB and disease progression in HTG-AP patients were analyzed.Results Among the 142 HTG-AP patients,41 cases progressed to severe acute pancreatitis(SAP),with an incidence of 28.87%(41/142),and the patients were included in the SAP group;among the remaining 101 cases,56 cases were MAP and 45 cases were MSAP.Serum levels of IL-17 and NF-κB in SAP patients were higher than those in MSAP and MAP patients,and the levels of IL-17 and NF-κB in MSAP patients were higher than those in MAP patients(P<0.05).The serum levels of IL-17 and NF-κB in SAP group were higher than those in NSAP group(P<0.05).Serum levels of IL-17 and NF-κB were positively correlated with the severity of HTG-AP patients(P<0.05).The AUC value of serum IL-17 and NF-κB combined to predict the disease progression of HTG-AP patients was greater than that of single index(P<0.05).Conclusion Elevated serum levels of IL-17 and NF-κB were increased the risk of disease progression in HTG-AP patients with or without adjusting for confounders.Serum levels of IL-17 and NF-κB are expected to be used as potential indicators to predict the disease progression of the patients.

关 键 词：急性高甘油三酯血症胰腺炎 核因子-ΚB 白细胞介素-17 重症急性胰腺炎 

分 类 号：R657.5[医药卫生—外科学]