1990—2019年中国人群2型糖尿病疾病负担及变化趋势分析  

Analysis of the disease burden and changing trend of diabetes mellitus type 2 in the Chinese population from 1990 to 2019

作　　者：夏小娟 黄方方 孙倩玉 潘莹宇 张海洋 贾秋萍 李慧蓉 XIA Xiaojuan;HUANG Fangfang;SUN Qianyu;PAN Yingyu;ZHANG Haiyang;JIA Qiuping;LI Huirong(Nanjing Jiangning District Center for Disease Control and Prevention,Nanjing,Jiangsu 211100,China;不详)

机构地区：[1]南京市江宁区疾病预防控制中心,江苏南京211100 [2]南京市江宁区第二人民医院 [3]南京市江宁区秣陵街道百家湖社区卫生服务中心

出　　处：《医学动物防制》2025年第3期230-236,241,共8页Journal of Medical Pest Control

基　　金：中国疾病预防控制中心关于2023年公共卫生领域卫生健康标准化前期研究项目(BZ2023-Q012)。

摘　　要：目的分析1990—2019年中国2型糖尿病(diabetes mellitus type 2,T2DM)疾病负担相关指标的时间变化趋势,为制定我国T2DM的预防政策和措施提供依据。方法从2019年全球疾病负担研究(global burden of disease,GBD)数据库中获取1990—2019年中国T2DM疾病负担指标数据,结合Joinpoint 5.0软件进行时间趋势分析,总趋势检验采用t检验,按年龄和性别分组讨论T2DM患病、发病、死亡和健康寿命年的损伤相关指标的变化和危害状况。结果2019年我国T2DM较1990年患病、发病和死亡人数分别增加159.67%、96.54%和162.76%,2019年T2DM患病率为6328.79/10万,发病率为262.88/10万,死亡率为11.84/10万。男性标化发病率和标化伤残损失寿命年(years lived with disability,YLDs)率年平均增长速度快于女性(YLDs:t=2.80,P=0.005),标化死亡率和标化因早死所致寿命损失年(years of life lost,YLLs)率男女总体趋势相反,女性表现为下降趋势。2019年15~<50岁年龄组发病率水平均较1990年上升。标化发病率的显著性增长主要分布在15~<45岁和70~<75岁年龄组,增长最快的为25~<30岁年龄组,平均年度变化百分比(average annual percent change,AAPC)为1.63%(t=11.13,P<0.001)。结论1990—2019年我国T2DM患病、发病和死亡人数均翻一番,T2DM仍是重要的公共卫生问题,男性较女性有更高的患病和死亡风险,青年群体发病风险和疾病负担逐渐增大。要加强青年群体的健康教育,结合生理-心理-社会因素,制定有针对性的预防措施和方案。Objective To analyze the time changing trend of indicators related to the burden of diabetes mellitus type 2(T2DM)in China from 1990 to 2019,and to provide a basis for formulating prevention policies and measures of T2DM in China.Methods Data on the burden of disease indicators for T2DM in China from 1990 to 2019 were obtained from the global burden of disease(GBD)database in 2019.The analysis of time trend was performed with Joinpoint 5.0 software.The t-test was used for the general trend test.The changes of indicators and harm status related to the suffering from an illness,incidence,death and impairment in healthy life years of T2DM were discussed by age and gender groups.Results Compared with 1990,the number of patients that suffered from an illness,incidence,and death of T2DM in China in 2019 increased by 159.67%,96.54%,and 162.76%,respectively.The prevalence rate of T2DM in 2019 was 6328.79/100000,the incidence rate was 262.88/100000,and the mortality rate was 11.84/100000.The average annual increase in the rates of standardized incidence rate and standardized rate of years lived with disability(YLDs)was faster for males than for females(YLDs:t=2.80,P=0.005).The overall trend in the rates of standardized mortality rate and standardized rate of years of life lost(YLLs)due to early death was reversed for males and females,with a downward trend for females.The incidence rate level in the age group of 15-<50 years in 2019 was higher than that of 1990.The significant increase in stardardilzed incidence rate was mainly distributed in the age groups of 15-<45 years and 70-<75 years,and the fastest increase was in the age group of 25-<30 years,with an average annual percent change(AAPC)of 1.63%(t=11.13,P<0.001).Conclusion The patients that suffered from an illness,incidence and deaths of T2DM in China doubls from 1990 to 2019.T2DM is still an important public health problem.Males have higher risk of suffering from an illness and death than females.The risk of incidence and the burden of disease is gradually increas

关 键 词：2型糖尿病 疾病负担 伤残调整寿命年 平均年度变化百分比 早死所致寿命损失年 分析 

分 类 号：R587.1[医药卫生—内分泌]