远志抗抑郁作用机制研究进展  

Antidepressant Mechanisms of Polygalae Radix:A Review

作　　者：刘黎明[1,2] 彭帅军 苏攀 栗俞程 LIU Liming;PENG Shuaijun;SU Pan;LI Yucheng(Henan Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao,Henan University of Chinese Medicine,Zhengzhou 450046,China;School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Academy of Chinese Medical Sciences,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学豫药全产业链研发河南省协同创新中心,郑州450046 [2]河南中医药大学药学院,郑州450046 [3]河南中医药大学中医药科学院,郑州450046

出　　处：《中国实验方剂学杂志》2025年第5期300-309,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学青年基金项目(82404882);河南省联合基金重点项目(232301420018);河南省自然科学青年基金项目(242300420428)。

摘　　要：抑郁症是一类高发性精神类疾病,其诱因复杂,发病机制涉及多个层面,至今尚未完全阐明,阻碍了新型高效抗抑郁药物的研发,严重影响人类身心健康并造成极大社会经济负担。目前抑郁症存在多种发病机制假说如单胺类神经递质紊乱、神经营养因子缺乏、神经可塑性损伤、谷氨酸紊乱、神经炎症紊乱、肠道菌群失衡及线粒体自噬障碍等。当前临床抗抑郁药物多为单胺类神经递质再摄取抑制剂,虽具有一定疗效但存在不良反应大、依从性低等缺点,而中医药具有多靶点、药效温和、不良反应少等特点,在抑郁症治疗中体现出显著优势。传统中药远志,具有安神益智、交通心肾、祛痰开窍之功效,在临床上常被用于治疗抑郁症的复方中。因此,该文基于当前抑郁症发病机制假说,从远志及活性成分、远志药对、含远志中药复方等多个层面,系统梳理远志抗抑郁作用机制研究进展,旨为远志的抗抑郁临床应用提供科学依据,也为远志抗抑郁现代化研究提供参考。Depression is a high-incidence mental disorder with complex causes and multifaceted pathogenic mechanisms.Its pathogenesis has not yet been fully elucidated,which has hindered the development of novel and highly effective antidepressant drugs.This condition severely affects human physical and mental health while imposing a significant socio-economic burden.At present,several hypotheses exist regarding the pathogenesis of depression,including monoamine neurotransmitter imbalances,neurotrophic factor deficiencies,neural plasticity impairments,glutamate dysregulation,neuroinflammatory disorders,gut microbiota imbalances,and mitochondrial autophagy dysfunction.Currently,most clinical antidepressants are monoamine neurotransmitter reuptake inhibitors.Although they exhibit certain therapeutic effects,they are associated with significant drawbacks,such as severe adverse reactions and poor patient compliance.In contrast,traditional Chinese medicine(TCM),characterized by its multi-targeted effects,mild efficacy,and minimal side effects,has demonstrated significant advantages in the treatment of depression.Chinese medicine Polygalae Radix possesses the functions of calming the mind,enhancing cognitive functions,harmonizing the heart and kidneys,and dispelling phlegm to open orifices.It is often included in compound prescriptions for the clinical treatment of depression.Based on current hypotheses regarding the pathogenesis of depression,this paper systematically reviews research progress on the antidepressant mechanisms of Polygalae Radix from multiple perspectives,including its active components,its use in herbal pairings,and its inclusion in TCM compound prescriptions.This review aims to provide a scientific basis for the clinical application of Polygalae Radix in antidepressant therapy and to serve as a reference for the modernization of its antidepressant research.

关 键 词：抑郁症 抗抑郁机制 远志及活性成分 远志药对 远志中药复方 

分 类 号：R259[医药卫生—中西医结合] R289[医药卫生—中医内科学] R242[医药卫生—中医学]