异鼠李素抗骨质疏松作用的研究进展  

Anti-osteoporosis Effect of Isorhamnetin:A Review

作　　者：孟世龙 张徐 徐亚伟 余阳 李威 曹延广 史晓林 张伟 刘康 MENG Shilong;ZHANG Xu;XU Yawei;YU Yang;LI Wei;CAO Yanguang;SHI Xiaolin;ZHANG Wei;LIU Kang(The Second School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou 310053,China;The Second Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310005,China;TCM Hospital Xianju of the Second Affiliated Hospital of Zhejiang Chinese Medical University,Taizhou 317300,China)

机构地区：[1]浙江中医药大学第二临床医学院,杭州310053 [2]浙江中医药大学附属第二医院,杭州310005 [3]浙江中医药大学附属第二医院仙居分院,浙江台州317300

出　　处：《中国实验方剂学杂志》2025年第5期347-352,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82274272);浙江省中医药重点研究项目(2022ZZ020);2024年浙江中医药大学研究生拔尖创新人才培育计划(2024YJSBJ006)。

摘　　要：骨质疏松症是一种常见的老年性骨代谢疾病,临床上以骨量降低、骨微结构破坏、骨脆性增加、易发生骨折为主要特点,好发于老年人和绝经后妇女,严重威胁老年人的生活质量和身心健康。目前,骨质疏松的治疗主要以口服西药为主,如钙剂和维生素D、双膦酸盐类等,但存在服药周期长、不良反应较多等不足。近年来,部分中药及有效成分因具有多成分、多途径、多靶点的优势,可以双向调节成骨和破骨分化过程,在骨质疏松的防治工作中应用广泛。沙棘是一种常用的中药材,其果实中富含黄酮类、多酚类、脂肪酸、维生素,以及多种微量元素,已被证实具有较好的抗骨质疏松功效。异鼠李素是沙棘果实的主要有效成分,具有抗炎、抗氧化应激、抗衰老、抗肿瘤等诸多药理作用。有研究表明,异鼠李素可以参与骨代谢的调控过程,具有较好的抗骨质疏松作用。但是,异鼠李素抗骨质疏松的药理作用和相关机制目前尚未进行系统的归纳和总结。因此,该文通过查阅相关文献,针对异鼠李素抗骨质疏松的药理作用及相关机制进行综述,以期为异鼠李素的开发和应用提供更多依据。Osteoporosis is a common senile bone metabolism disease,clinically characterized by decreased bone mass,destruction of bone microstructure,increased bone fragility,and easy fracture.It tends to occur in the elderly and postmenopausal women,seriously threatening the quality of life and physical and mental health of the elderly.At present,the treatment of osteoporosis is mainly based on oral western medicines,such as calcium,Vitamin D,and bisphosphonates.Still,there are drawbacks such as a long medication cycle and many adverse reactions.In recent years,due to the advantages of multi-component,multi-pathway,and multi-target,some traditional Chinese medicines and effective ingredients can regulate the osteogenic and osteoclastic differentiation process in both directions and are widely used in the prevention and treatment of osteoporosis.Hippophae rhamnoides is a commonly used herbal medicine,and its fruits are rich in flavonoids,polyphenols,fatty acids,vitamins,and trace elements,which have been proven to have a good anti-osteoporosis effect.Isorhamnetin is the main effective ingredient of Hippophae rhamnoides fruits,which has many pharmacological effects such as anti-inflammation,anti-oxidative stress,anti-aging,and anti-tumor.Studies have shown that isorhamnetin can participate in the regulation of bone metabolism and has a good anti-osteoporosis effect.However,the pharmacological effects and related mechanisms of isorhamnetin against osteoporosis have not been systematically summarized.Therefore,this paper reviewed the pharmacological effects and related mechanisms of isorhamnetin against osteoporosis by referring to relevant literature to provide more basis for the development and application of isorhamnetin.

关 键 词：异鼠李素 骨质疏松 作用机制 研究进展 

分 类 号：R285[医药卫生—中药学] R274[医药卫生—中医学] R282