Q fever diagnosed using metagenomic next-generation sequencing in Guangdong Province,China  

作　　者：Ting Hu Yuan Cheng Jia Wan Yandong Liu Yali Zhuang Mengxi Zhou Xin Zhang Xiaohua Tan Aiping Deng Meng Zhang Peng Wang Xiaoying Li Jun Zong Lihong Cheng Min Kang 

机构地区：[1]Institute of Infectious Disease Control and Prevention,Guangdong Provincial Center for Disease Control and Prevention,Guangzhou 511430,China [2]Wuyuan Center for Disease Control and Prevention,Shangrao 333200,China [3]Institute of Infectious Disease Control and Prevention,Shenzhen Center for Disease Control and Prevention,Shenzhen 518000,China [4]Huizhou Center for Disease Control and Prevention,Huizhou 516000,China [5]Guangdong Field Epidemiology Training Program,Nanhai Center for Disease Control and Prevention,Foshan 528200,China [6]Institute of Pathogenic Microbiology,Guangdong Provincial Center for Disease Control and Prevention,Guangzhou 511430,China [7]Jiangxi Provincial Center for Disease Control and Prevention,Nanchang 330029,China [8]Key Laboratory of Epidemic Prevention and Control in Jiangxi Province,Nanchang 330029,China

出　　处：《Biosafety and Health》2024年第6期337-340,共4页生物安全与健康(英文)

基　　金：supported by The Key-Area Research and Development Program of Guangdong Province (2022B1111020006);The Medical Scientific Research Foundation of Guangdong Province, China, 2024 (A2024600). We thank all the participants in the study.

摘　　要：Q fever is a zoonotic disease caused by infection withCoxiella burnetii(C.burnetii).Due to its atypical symptoms and the absence of specific detection methods,Q fever is underdiagnosed commonly.Herein,we report a case of Q fever confirmed by metagenomic next-generation sequencing(mNGS)in March 2024 in Guangdong Province,China.The patient initially experienced fever and was admitted to hospital six days later.Despite a series of laboratory tests conducted at the hospital,the pathogen remained undetermined.Ten days after admission,mNGS revealed that the patient was infected withC.burnetii.The patient subsequently underwent treatment with doxycycline and recovered well.Epidemiological investigation revealed that the patient had been exposed to sheep infected withC.burnetii without any protective measures in Jiangxi Province,China.Based on the comprehensive results of mNGS,exposure history,clinical manifestations and treatment response,the patient was confirmed as a Q fever case.As a neglected and underestimated illness,Q fever necessitates an elevation in awareness among medical staff and the public.The public should be encouraged to take personal protective measures when exposed to livestock.Further research is needed to explore the rational application of mNGS in the diagnosis of uncommon and unknown diseases.

关 键 词：Q fever Coxiella burnetii(C.burnetii) Zoonotic disease 

分 类 号：R513.4[医药卫生—内科学]