Molecular epidemiological study on tick-borne pathogens in Qinghai Province,Northwestern China  

作　　者：Chunfeng Luo Yonghong Song Luoyuan Xia Minxuan Liu Hao Feng Licheng Xiao Ming Xu Xiangyin Cai Jianye Cui Rong Xiang Jihu Yang Wei Kan Yanli Shen Yuanlian Ma Zhanhao Zeng Baohan Liu Yulian Tao Huimin Yu Yi Sun Xiaorun Wang Jiafu Jiang 

机构地区：[1]Department of Epidemiology and Health Statistics,School of Public Health,Anhui Medical University,Hefei 230032,China [2]State Key Laboratory of Pathogen and Biosecurity,Academy of Military Medical Sciences,Beijing 100071,China [3]Qinghai Provincial Animal Disease Prevention and Control Center,Xining 810000,China [4]College of Veterinary Medicine,Gansu Agricultural University,Lanzhou 730000,China [5]State Key Laboratory Animal Disease Control and Prevention,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046,China [6]Yushu City Animal Husbandry and Veterinary Station,Xining 815000,China [7]Huzhu County Animal Husbandry and Veterinary Station,Xining 810500,China [8]Ledu District Animal Husbandry and Veterinary Station,Xining 810700,China

出　　处：《Biosafety and Health》2024年第6期361-368,共8页生物安全与健康(英文)

基　　金：funded by the National Natural Science Foundation of China(U2002219);The datasets generated or analyzed during the current study are available from the corresponding author on reasonable request;All the nucleotide sequences obtained in this study are available in the GenBank of National Center for Biotechnology Information with accession numbers OR805110-OR805127,OR792783-OR792797,OR793990-OR793998,and OR813910-OR813915.

摘　　要：Recently,there has been a continuous stream of reports on emerging tick-borne pathogens affecting humans.Qinghai Province,located in the northweastern region,is one of China’s major pastoral areas,providing a suitable environment for ticks''survival and transmitting tick-borne pathogens.Here,we collected 560 free-living and parasitic ticks from 11 locations in Qinghai Province using the flag-drag method or tweezers,identifying them as belonging to 4 species of ticks.The overall positivity rate for tick-borne pathogens was 51.61%,comprisingRickettsia(34.64%),Anaplasma(5.00%),Ehrlichia(2.14%),Borrelia burgdorferi sensu lato(BBSL)(7.50%),Babesia(0.18%),andTheileria(5.89%).Sequencing revealed the presence of 7 species ofRickettsia,4 species ofAnaplasma,2 species ofEhrlichia,2 species of BBSL,1 species ofBabesia,and 3 species ofTheileria.Among the ticks,6.43%were co-infected with 2 pathogens,while 0.36%exhibited co-infection with 3 pathogens.Significant correlations(P<0.05)were observed between the prevalence of tick-borne pathogens and factors including tick species,sex,developmental stages,parasitic status,and blood-feeding status.The results highlight the diverse distribution of tick-borne pathogens in Qinghai Province,posing a significant threat to both local animal husbandry and human health.It underscores the need to enhance systematic monitoring of tick-borne pathogens in the local population and livestock.

关 键 词：TICK Tick-borne pathogens CO-INFECTION Distribution of Qinghai Province 

分 类 号：R53[医药卫生—内科学] R181.3[医药卫生—临床医学]