大柴胡汤加减治疗2型糖尿病随机对照试验Meta分析  

Meta-Analysis of Randomized Controlled Trials for Modified Da Chaihu Decoction in the Treatment of Type 2 Diabetes Mellitus

作　　者：王筠禹 方朝晖[2,3] WANG Yun-yue;FANG Zhao-hui(Anhui University of Traditional Chinese Medicine,Hefei 230038,China;The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230032,China;Key Laboratory of Xin'an Medicine,Ministry of Education,Anhui University of Traditional Chinese Medicine,Hefei 230031,China)

机构地区：[1]安徽中医药大学,安徽合肥230038 [2]安徽中医药大学第一附属医院,安徽合肥230032 [3]新安医学教育部重点实验室(安徽中医药大学),安徽合肥230031

出　　处：《云南中医中药杂志》2025年第2期57-63,共7页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

基　　金：国家自然科学基金项目(82174153);合肥综合性国家科学中心大健康研究院新安医学与中医药现代化研究所“揭榜挂帅”项目(2023CXMMTCM003);安徽高校协同创新项目(GXXT-2020-025);2021年安徽省医疗卫生重点专科项目(wszdxkjs20210047);安徽省重大疑难疾病中西医协同攻关项目(zyyktyj20210093);安徽中医药大学第一附属医院临床科研项目(2020yfyzc14)。

摘　　要：目的评价单独运用大柴胡汤加减治疗2型糖尿病(type 2 diabetes mellitus,T2DM)的临床疗效及用药安全性。方法通过检索中国知网、维普、万方、PUBMED等数个权威中英文数据库中收录的有关大柴胡汤加减治疗2型糖尿病的随机对照试验(randomized controlled trials,RCTs)。检索时间范围涵盖各数据库建库至2023年7月。设置3名研究者,通过严明的分工合作,依据纳入和排除标准对所检索文献进行筛选,评估文献方法质量,并对高质量文献进行研读和数据挖掘,分析时运用RevMan5.4软件完成具体操作。结果共纳入8篇RCT文献,共670例患者。Meta分析结果显示:单独运用大柴胡汤加减治疗与对照组对比,空腹血糖(MD=-0.48,95%CI[-0.85,-0.10],Z=2.48,P=0.01)、2h PG(MD=-0.75,95%CI[-1.35,-0.14],Z=2.42,P=0.02)、糖化血红蛋白(MD=-0.16,95%CI[-0.38,-0.05],Z=1.47,P<0.01],P<0.0009)、中医证候评分(MD=-6.32,95%CI[-7.85,-4.80],Z=8.13,P<0.00001)、TC(MD=-0.88,95%CI[-1.07,-0.70],Z=9.54,P<0.00001)的疗效均优于对照组,差异有统计学意义,且不良反应发生率较低。结论单独运用大柴胡汤加减在改善T2DM患者血糖和相应临床症状方面疗效显著,具有广阔的临床应用价值且用药安全系数高。Objective:To evaluate the clinical efficacy and safety of using modified Da Chaihu Decoction alone in the treatment of type 2 diabetes mellitus(T2DM).Methods:A comprehensive search was conducted across several authoritative Chinese and English databases,including CNKI,VIP,Wanfang,and PubMed,for randomized controlled trials(RCTs)on modified Da Chaihu Decoction for T2DM.The search period spanned from database inception to July 2023.Three researchers independently screened the retrieved literature according to inclusion and exclusion criteria,assessed methodological quality,and reviewed high-quality studies for data extraction.Data analysis was performed by using RevMan 5.4 software.Results:Eight RCTs involving 670 patients were included.Meta-analysis revealed that the treatment with modified Da Chaihu Decoction alone,compared to the control group,significantly improved fasting blood glucose(MD=-0.48,95%CI[-0.85,-0.10],Z=2.48,P=0.01),2-hour postprandial glucose(2h PG)(MD=-0.75,95%CI[-1.35,-0.14],Z=2.42,P=0.02),glycated hemoglobin(HbA1c)(MD=-0.16,95%CI[-0.38,-0.05],Z=1.47,P<0.01,P<0.0009),TCM syndrome scores(MD=-6.32,95%CI[-7.85,-4.80],Z=8.13,P<0.00001),and total cholesterol(TC)(MD=-0.88,95%CI[-1.07,-0.70],Z=9.54,P<0.00001).The differences were statistically significant,and the incidence of adverse reactions was relatively low.Conclusion:Modified Da Chaihu Decoction alone demonstrates significant efficacy in improving blood glucose levels and clinical symptoms in T2DM patients,and has broad clinical application value and high drug safety factor.

关 键 词：2型糖尿病 大柴胡汤加减 单独应用 随机对照试验 

分 类 号：R587.1[医药卫生—内分泌]