昆虫抗菌肽的炎症抑制功能及研究进展  

Research on the Progress of Anti-inflammatory Function of Insect Antimicrobial Peptides(AMPs)

作　　者：许方正 夏万军 陈卓志 石燕超 冯梦佳 刘虹宇 杨婉莹[1] Xu Fangzheng;Xia Wanjun;Chen Zhuozhi;Shi Yanchao;Feng Mengjia;Liu Hongyu;Yang Wanying(College of Animal Science,South China Agricultural University,Guangzhou Guangdong,510642)

机构地区：[1]华南农业大学动物科学学院,广东广州510642

出　　处：《广东蚕业》2025年第1期51-58,共8页Guangdong Sericulture

基　　金：国家自然科学基金面上项目(32270515);广东省基础与应用基础研究基金(2023A1515010172);华南农业大学大学生创新创业训练计划项目(省级2023年度)。

摘　　要：炎症(inflammation)是机体的正常生理反应,其作用是抗感染、促进伤口愈合,从而促进机体恢复,但过度或长期的炎症反应会诱发多种疾病甚至癌症。因此,阻断炎症信号通路继而控制炎症的发生发展就成为免疫研究中的热点。研究发现,抗菌肽(antimicrobial peptides, AMPs)除了具有良好的抗细菌、抗病毒和抗肿瘤特性,还能够抑制哺乳动物炎症信号通路,抑制败血病等细胞因子风暴类的疾病。文章综述了哺乳动物炎症发生机理和信号通路,介绍了昆虫抗菌肽在抑制炎症中的作用机制,以期为昆虫抗菌肽进一步的功能研究和生产开发提供新思路。Inflammation is a normal physiological response of the body,which serves to fight infection,accelerate wound healing,and thus facilitate recovery.However,excessive or prolonged inflammation can induce a variety of diseases and even cancer.Therefore,blocking the inflammatory signaling pathway and then controlling inflammation has become a hot spot in immune research.In recent years,it has been found that AMPs,in addition to itsexcellent antibacterial,antiviral and antitumor properties,can also inhibit the mammalian inflammatory signaling pathway and inhibit sepsis and other cytokine storm-like diseases.In view of this,the mechanism of mammalian inflammation and signaling pathways were reviewed,focusing on the mechanism of insect AMPs in the inhibition of inflammation,in the hope of providing new ideas for further research and development of insect AMPs.

关 键 词：昆虫抗菌肽 炎症反应 炎症抑制 作用机理 

分 类 号：R915[医药卫生—微生物与生化药学]