久居西藏高原地区健康人群Willis环形态变异发生情况及影响因素  

Occurrence and influencing factors of morphological variations of circle of Willis in healthy individuals living in Tibet plateau region for an extended period

作　　者：尚邹潇 李世海 唐毅 薛华 刘曙东 杨德雨[1,4] SHANG Zouxiao;LI Shihai;TANG Yi;XUE Hua;LIU Shudong;YANG Dengyu(Department of Neurology,Yongchuan Hospital of Chongqing Medical University,Chongqing 402160,China;不详)

机构地区：[1]重庆医科大学附属永川医院神经内科,重庆402160 [2]昌都市人民医院放射科,西藏昌都854000 [3]昌都市人民医院内一科,西藏昌都854000 [4]脑血管病研究重庆市重点实验室,重庆402160

出　　处：《山东医药》2025年第2期1-5,共5页Shandong Medical Journal

基　　金：西藏自治区自然科学基金组团式援藏医学项目(XZ2020ZR-ZY68-Z);重庆市永川区自然科学基金计划项目(022yc-jckx20053)。

摘　　要：目的观察久居西藏高原地区健康人群大脑动脉环(Willis环)的形态变异发生情况,并分析Willis环完整性的影响因素。方法选择久居西藏高原地区的健康人群334例,汉族214例、藏族120例。采用头颅磁共振和磁共振血管成像检查评估Willis环形态及完整性。收集研究对象的性别、年龄、民族、身体质量指数(BMI)、居住地海拔、高原地区居住时间、吸烟史、饮酒史等资料,分析Willis环形态完整性的影响因素。结果334例研究对象中,Willis环完整85例、部分完整210例、不完整39例,Willis环完整率为24.9%。Willis环前循环完整288例、后循环完整92例。藏族人群前循环完整率高于汉族人群(P<0.05)。Willis环形态变异(部分完整+不完整)249例(74.6%),前循环变异46例(13.8%)、后循环变异242例(72.5%)。藏族人群Willis环完整率高于汉族人群,女性Willis环完整率高于男性(P均<0.05)。Willis环完整率与年龄、BMI、吸烟、饮酒、居住地海拔、高原地区居住时间无关(P均>0.05)。将民族、性别、吸烟因素纳入Logistic回归分析,结果显示,民族是Willis环完整性的独立影响因素,藏族是Willis环完整性的保护因素(OR=0.594,95%CI 0.357~0.997)。结论久居西藏高原地区健康人群Willis环形态变异发生率较高,以后循环形态变异为主;民族是Willis环完整性的独立影响因素,藏族人群Willis环完整率高于汉族人群。Objective To observe the occurrence of morphological variations of the cerebral arterial ring(circle of Willis)in healthy people who have long resided in the Tibetan plateau region,and to analyze the factors affecting the com pleteness of the circle of Willis.Methods Totally 334 cases of healthy people living in the Tibetan plateau region were selected,214 cases of Han nationality and 120 cases of Tibetan.Cranial magnetic resonance and magnetic resonance angiog raphy were used to assess the circle of Willis morphology and completeness.Data on sex,age,ethnicity,body mass index(BMI),altitude of residence,duration of residence in the plateau region,history of smoking,and history of drinking were collected from the study subjects to analyze the factors affecting the completeness of the circle of Willis.Results Among 334 study subjects,85 cases of circle of Willis were complete,210 cases were partially complete and 39 cases were incom plete,and the completeness rate of circle of Willis was 24.9%.There were 288 cases of complete anterior circulation and 92 cases of complete posterior circulation of circle of Willis.The rate of complete anterior circulation was higher in the Tibetan population than in the Han population(P<0.05).There were 249 cases of circle of Willis morphologic variations(partially complete+incomplete)(74.6%),46 cases of anterior circulation variations(13.8%,of which 29 were E-type variations),and 242 cases of posterior circulation variations(72.5%,of which 61 were E-type and 73 were G-type).The circle of Willis completeness rate was higher in Tibetan population than in Han population,and the circle of Willis com pleteness rate was higher in females than in males(all P<0.05).The circle of Willis completeness rate was not related to age,BMI,smoking,alcohol consumption,altitude of residence,or duration of residence in plateau area(all P>0.05).Ethnicity,gender,and smoking influences were further incorporated into Logistic regression analysis,and the Logistic re gression analysis showed that ethnicity was

关 键 词：大脑动脉环 WILLIS环 Willis环形态变异 西藏高原人群 磁共振血管成像 脑卒中 

分 类 号：R599[医药卫生—内科学] R602[医药卫生—临床医学]