生酮饮食治疗难治性癫痫患儿的常见不良反应及应对策略研究进展  

Research progress on common adverse reactions and coping strategies of ketogenic diet in the treatment of refractory epilepsy in children

作　　者：李昕阳 姚宝珍[1] LI Xinyang;YAO Baozhen(Department of Pediatrics,People's Hospital of Wuhan University,Wuhan 430030,China)

机构地区：[1]武汉大学人民医院儿科,湖北武汉430030

出　　处：《山东医药》2025年第2期135-138,143,共5页Shandong Medical Journal

基　　金：武汉大学腾飞计划(TFLC2018001)。

摘　　要：难治性癫痫(RE)是指使用两种或两种以上的抗癫痫药物治疗后,仍不能得到良好控制的癫痫。生酮饮食(KD)是一种高脂肪、低碳水化合物的饮食,目前已逐渐用于儿童RE的辅助治疗中。KD治疗RE患儿的常见不良反应包括消化系统、内分泌系统、中枢神经系统、泌尿系统和血液系统不良反应等,可以通过明确儿童RE病因、改变KD治疗方案、母乳喂养、控制低血糖、监测血脂、补充其他营养素、改变抗癫痫药物剂型、定期进行KD疗效评估等应对策略减轻这些不良反应。深入了解KD治疗儿童RE的常见不良反应及应对策略,有助于提高临床医师制定更科学的KD诊疗策略,提高KD治疗儿童RE的效果。Refractory epilepsy(RE)refers to epilepsy that can not be well controlled after treatment with two or more antiepileptic drugs.Ketogenic diet(KD)is a high-fat,low carbohydrate diet that has gradually been used as an adjuvant therapy for childhood RE.The common adverse reactions of KD treatment for children with RE include digestive system,endocrine system,central nervous system,urinary system,and hematological system adverse reactions.These adverse re actions can be alleviated by identifying the cause of RE in children,changing the KD treatment plan,breastfeeding,con trolling hypoglycemia,testing blood lipids,supplementing other nutrients,changing the dosage form of antiepileptic drugs,and conducting regular KD efficacy evaluations.A deeper understanding of the common adverse reactions and cop ing strategies of KD treatment for pediatric RE can help clinical physicians develop more scientific KD diagnosis and treat ment strategies,and improve the effectiveness of KD treatment for RE in children.

关 键 词：儿童癫痫 难治性癫痫 生酮饮食 不良反应 

分 类 号：R725[医药卫生—儿科]