烟雾病治疗的研究进展  

Research progress in the treatment of moyamoya disease

作　　者：刘瑞芳 武青云 王娣 李继锋 LIU Ruifang;WU Qingyun;WANG Di;LI Jifeng(Department of Neurology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250012,China;不详)

机构地区：[1]山东第一医科大学附属省立医院神经内科,山东济南250012 [2]山东第一医科大学(山东省医学科学院)研究生部,山东济南250117 [3]首都医科大学宣武医院济南医院,山东济南250101

出　　处：《山东医药》2025年第2期139-143,共5页Shandong Medical Journal

基　　金：山东省重点研发计划项目(2016GSF201068)。

摘　　要：烟雾病是一种慢性闭塞性脑血管疾病,以双侧颈内动脉颅内段及其近端分支进行性狭窄或闭塞并异常侧支血管形成为特点,是导致急性脑卒中的一大重要病因。烟雾病在东亚国家高发,且有一定的家族聚集性。该病病因尚不明确,可能与遗传、血管炎症、免疫损伤等因素相关。其治疗主要包括手术治疗和药物治疗,手术治疗包括直接血管重建术、间接血管重建术及联合血管重建术,药物治疗主要选用抗血小板药物、抗凝药物、他汀类药物、钙通道阻滞剂、脑细胞保护及改善循环等药物。目前尚无可以逆转或阻止烟雾病进展的有效手段,手术及药物治疗的获益也并不确切。Moyamoya disease is a chronic occlusive cerebrovascular disease characterized by progressive stenosis or occlusion of the intracranial segment of the bilateral internal carotid artery and its proximal branches and abnormal collater al vessel formation.The etiology of the disease is not clear,which may be related to genetic,vascular inflammation,im mune injury and other factors.The treatment mainly includes surgical treatment and drug treatment.Surgical treatment in cludes direct vascular reconstruction,indirect vascular reconstruction and combined vascular reconstruction.Drug treat ment mainly includes antiplatelet drugs,anticoagulant drugs,statins,calcium channel blockers,brain cell protection and circulation improvement drugs.At present,there is no effective means to reverse or prevent the progression of moyamoya disease,and the benefits of surgery and drug treatment are not exact.

关 键 词：烟雾病 外科手术 脑血管重建术 药物治疗 血小板聚集抑制剂 

分 类 号：R743[医药卫生—神经病学与精神病学]