PD-1/PD-L1在脓毒症免疫调节机制中的研究进展  

Research progress of PD-1/PD-L1 in immune regulation mechanism of sepsis

作　　者：王嘉馨 黄潇 郝东[1] WANG Jiaxin;HUANG Xiao;HAO Dong(Department of Critical Care Medicine,Binzhou Medical University Hospital,Shandong,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院重症医学科,山东滨州256600

出　　处：《中国医药科学》2025年第3期24-27,共4页China Medicine And Pharmacy

基　　金：山东省自然科学基金青年项目(ZR2021QH105)。

摘　　要：脓毒症是一种危及生命的感染反应,引起长期的免疫抑制和较高的复发感染率,出院后的患者仍面临着严峻的病死风险。脓毒症引起的免疫抑制,被认为是导致病死率增加的重要原因。临床研究表明程序性细胞死亡蛋白1(PD-1)与程序性细胞死亡蛋白配体1(PD-L1)通过负性调节宿主免疫能力介导免疫平衡,影响机体器官功能,增加病死风险。本文综述PD-1/PD-L1在脓毒症免疫调节机制中的重要作用,并表明该通路可能是脓毒症的潜在治疗靶点。Sepsis is a life-threatening infectious response that causes long-term immune suppression and a high rate of recurrent infections.Even after discharge,patients still face a severe risk of death.The immune suppression caused by sepsis is considered an important cause of increased mortality.Clinical studies have shown that programmed cell death protein 1(PD-1)and programmed cell death protein ligand 1(PD-L1)negatively regulate host immune function,mediate immune balance,affect organ function,and increase the risk of death.This paper reviews the important role of PD-1/PD-L1 in the immune regulatory mechanism of sepsis and suggests that this pathway may be a potential therapeutic target for sep sis.

关 键 词：脓毒症 免疫调节 程序性细胞死亡蛋白1 程序性细胞死亡蛋白配体1 

分 类 号：R459.7[医药卫生—急诊医学]