不动杆菌碳青霉烯耐药基因及传播机制研究进展  

Research progress on carbapenem resistance genes and their mechanisms of transmission in Acinetobacter

作　　者：唐克 耿婉如[2] 宋颖 刘新博 李楠[1] TANG Ke;GENG Wanru;SONG Ying;LIU Xinbo;LI Nan(Graduate School,Inner Mongolia Minzu University,Inner Mongolia,Tongliao 028000,China;Department of Infectious Diseases,Affiliated Hospital of Inner Mongolia Minzu University,Inner Mongolia,Tongliao 028000,China)

机构地区：[1]内蒙古民族大学研究生院,内蒙古通辽028000 [2]内蒙古民族大学附属医院感染性疾病科,内蒙古通辽028000

出　　处：《中国医药科学》2025年第3期28-31,共4页China Medicine And Pharmacy

基　　金：内蒙古自治区自然科学基金项目(2024MS08084)。

摘　　要：以鲍曼不动杆菌为代表的不动杆菌属广泛存在于自然界,能引起肺炎、血流感染、伤口感染、尿路感染和导管相关感染。随着碳青霉烯类抗生素在临床上逐渐应用,碳青霉烯耐药不动杆菌也随之出现并不断传播,极大地增加了临床抗感染治疗的挑战性,因此,进一步了解不动杆菌碳青霉烯耐药基因及传播机制尤为重要。本文旨在通过对不动杆菌碳青霉烯耐药基因的既往研究进行综述,寻找更加经济有效的方法检测和干预耐药性,并阻止新的耐药基因的出现,也为新的治疗方法提供理论依据。The Acinetobacter,represented by Acinetobacter baumannii,is widely found in nature and can lead to pneumonia,bloodstream infections,wound infections,urinary tract infections,and catheter-associated infections.With the gradual clinical application of carbapenem antibiotics,the emergence and continuous spread of carbapenem-resistant Acinetobacter have posed significant challenges to clinical anti-infective therapies.Therefore,a deeper understanding of the carbapenem resistance genes and their mechanisms of transmission in Acinetobacter is of great importance.This paper aims to review previous studies on carbapenem resistance genes in Acinetobacter,to identify more cost-effective methods for detecting and intervening resistance,to prevent the emergence of new resistance genes,and to provide a theoretical basis for the development of new therapeutic approaches.

关 键 词：碳青霉烯 抗生素 不动杆菌 耐药基因 水平基因转移 

分 类 号：R378[医药卫生—病原生物学]