连豆清脉方对陈旧性心肌梗死PCI术后慢血流患者西雅图心绞痛量表评分及血清指标的影响  

Effects of Liandou Qingmai Recipe on the scores of the Seattle Angina Questionnaire and serum indicators in patients with slow blood flow after percutaneous coronary intervention for old myocardial infarction

作　　者：廖文琦 赵浩延 徐振海 曹鹏飞 胡斌 LIAO Wenqi;ZHAO Haoyan;XU Zhenhai;CAO Pengfei;HU Bin(Department of Emergency Medicine,Xuzhou Hospital of Traditional Chinese Medicine,Jiangsu,Xuzhou 221000,China;Department of Pain,Changzhou Cancer Hospital,Jiangsu,Changzhou 213032,China)

机构地区：[1]江苏省徐州市中医院急诊医学科,江苏徐州221000 [2]江苏省常州市肿瘤医院疼痛科,江苏常州213032

出　　处：《中国医药科学》2025年第3期98-101,163,共5页China Medicine And Pharmacy

基　　金：江苏省中医药科技发展计划项目(YB2020048)。

摘　　要：目的 探讨连豆清脉方对陈旧性心肌梗死经皮冠状动脉介入治疗(PCI)术后慢血流患者西雅图心绞痛量表(SAQ)评分、白细胞介素(IL)-12p70、IL-17A、血清胱抑素-C(Cys-C)、C反应蛋白(CRP)等浓度的影响。方法 选取2022年12月至2023年12月徐州市中医院收治的临床表现为心绞痛的陈旧性心肌梗死PCI术后患者80例为研究对象,冠状动脉造影检查均诊断为冠状动脉慢血流。术后根据患者入院单双日的顺序将其分为观察组(44例)和对照组(36例)。对照组接受标准冠状动脉粥样硬化性心脏病二级预防药物治疗,观察组在对照组的治疗方案上加用连豆清脉方治疗。观察患者治疗前及治疗后1周SAQ评分、IL-12p70、IL-17A、Cys-C、CRP、丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、血肌酐(Scr)浓度的变化。结果 治疗前,两组SAQ各维度评分比较,差异无统计学意义(P> 0.05);治疗后,观察组SAQ各维度评分均高于对照组,差异有统计学意义(P <0.05)。治疗前,两组IL-12p70、IL-17A比较,差异无统计学意义(P> 0.05);治疗后,观察组IL-12p70明显低于治疗前,差异有统计学意义(P <0.05)。治疗前,两组Cys-C、CRP比较,差异无统计学意义(P> 0.05);治疗后,观察组Cys-C低于对照组,差异有统计学意义(P <0.05)。治疗前后两组患者肝、肾功能比较,差异无统计学意义(P> 0.05)。结论 连豆清脉方能改善陈旧性心肌梗死PCI术后慢血流患者心绞痛症状,其作用机制可能与改善血管炎症反应有关。Objective To investigate the effects of Liandou Qingmai Recipe on the scores of the Seattle angina questionnaire(SAQ),interleukin(IL)-12p70,IL-17A,cystatin-C(Cys-C)and C-reactive protein(CRP)concentrations in patients with slow blood flow after percutaneous coronary intervention(PCI)for old myocardial infarction.Methods A total of 80 patients patients with slow blood flow after PCI for old myocardial infarction at Xuzhou Hospital of Traditional Chinese Medicine from December 2022 to December 2023 were selected as the study subjects.Coronary angiography diagnosed them with coronary slow flow.After surgery,patients were divided into an observation group(44 cases)and a control group(36 cases)according to the order of single and double days of admission..The control group was treated with standard secondary prevention drugs for coronary atherosclerotic heart disease,and the observation group was treated with Liandou Qingmai Recipe in addition to the treatment scheme of the control group.Observe the SAQ scores of patients before and 1 week after treatment IL-12p70、IL-17A、Cys-C、CRP、Changes in the concentrations of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and serum creatinine(Scr).Results Comparison of the scores of various SAQ dimensions between the two groups before treatment showed no statistically significant difference(P>0.05).The scores of various SAQ dimensions were higher in the observation group than those in the control group after treatment,with statistically significant differences (P < 0.05). Comparison of IL-12p70 and IL-17A between the two groups before treatment showed no statistically significant difference (P > 0.05). IL-12p70 in the observation group was significantly lower than that before treatment, with a statistically significant difference (P < 0.05). Comparison of Cys-C and CRP between the two groups before treatment showed no statistically significant difference (P > 0.05). Cys-C was lower in the observation group than that in the control group after treatment, with

关 键 词：连豆清脉方 冠状动脉慢血流 SAQ 血清胱抑素-C C反应蛋白 

分 类 号：R259[医药卫生—中西医结合]