口炎清颗粒联合康复新液对复发性口腔溃疡临床疗效、复发率及炎症水平影响的回顾性研究  

Retrospective Study of Kouyanqing Granules(口炎清颗粒)Combined with Kangfuxin Liquid(康复新液)on Clinical Efficacy,Recurrence Rate and Inflammation Level of Patients with Recurrent Oral Ulcer

作　　者：王琛霓[1] 李海朋[1] 黄莹莹[1] WANG Chenni;LI Haipeng;HUANG Yingying(The First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,Henan,China)

机构地区：[1]南阳医学高等专科学校第一附属医院,河南南阳473000

出　　处：《中华中医药学刊》2025年第2期96-99,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家重点研发计划“常见多发病防治研究”重点专项(2021YFC2501200);中华医学会临床医学科研专项(17020085326);河南省高校科技创新人才支持计划项目(16IRTS THN025)。

摘　　要：目的观察口炎清颗粒联合康复新液治疗复发性口腔溃疡临床疗效、复发率及其对患者血清炎症水平的影响。方法选择2020年1月—2022年9月于南阳医学高等专科学校第一附属医院口腔科治疗的60例轻复发性口腔溃疡患者作为研究对象,采用随机数字表法将上述患者分为常规治疗组和口炎清组,每组30例,常规治疗组予以康复新液含漱治疗,口炎清组在常规治疗组基础上予以口炎清颗粒口服治疗。比较两组患者的临床疗效、临床症状、复发率和不良反应情况,以及干预前后血清炎症因子和免疫功能变化。结果常规治疗组有效率为73.33%(22/30),口炎清组有效率为93.33%(28/30),与常规治疗组比较,口炎清组的有效率明显升高(P<0.05)。与常规治疗组比较,口炎清组疼痛持续时间、创面愈合时间以及进食改善时间均明显缩短,差异具有统计学意义(P<0.01,P<0.05)。干预完成后,口炎清组患者外周血中CD_(3)^(+)、CD_(4)^(+)以及CD_(4)^(+)/CD_(8)^(+)水平相较于常规治疗组均明显升高,而CD_(8)^(+)水平则明显下降(P<0.01,P<0.05)。干预完成后,口炎清组的血清白介素(interleukin,IL)-1、IL-6以及肿瘤坏死因子(tumor necrosis factor,TNF)-α水平相较于常规治疗组均明显下降(P<0.01)。干预完成后3个月、6个月时两组复发率差异无统计学意义(P>0.05);但相较于常规治疗组,口炎清组患者的总复发率明显降低(P<0.05)。干预过程中两组均未发生明显药物相关不良反应或过敏反应。结论口炎清颗粒联合康复新液治疗复发性口腔溃疡具有良好临床效果,能够明显改善患者的临床症状、降低复发率,其作用机制与抑制血清炎症反应、调节机体免疫功能相关。Objective To observe the clinical efficacy,recurrence rate and serum inflammation of patients with recurrent oral ulcer treated by Kouyanqing Granules(口炎清颗粒)combined with Kangfuxin Liquid(康复新液).Method Sixty patients with mild recurrent oral ulcer treated in the stomatology department of the hospital from January 2020 to September 2022 were selected as the research objects.The patients were divided into conventional treatment group and Kouyanqing Granules group by random number table method,with 30 cases in each group.The conventional treatment group was given Kangfuxin Liquid.The Kouyanqing Granules group was orally treated with Kouyanqing Granules on the basis of conventional treatment group.The clinical efficacy,clinical symptoms,recurrence rate and adverse reactions of the two groups were compared as well as the changes of serum inflammatory factors and immune function before and after intervention.Results The effective rate of the conventional treatment group was 73.33%(22/30)and that of Kouyanqing Granules group was 93.33%(28/30).Compared with the conventional treatment group,the effective rate of the Kouyanqing Granules group was significantly increased(P<0.05).Compared with those of the conventional treatment group,the pain duration,wound healing time and feeding improvement time in the Kouyanqing Granules group were significantly shortened and the differences were statistically significant(P<0.01,P<0.05).After the intervention,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in peripheral blood of the Kouyanqing Granules group were significantly higher than those of the conventional treatment group,while the levels of CD8^(+)were significantly decreased(P<0.01,P<0.05).After the intervention,the serum levels of IL-1,IL-6 and TNF-αin the Kouyanqing Granules group were significantly decreased compared with those in the conventional treatment group(P<0.01).There was no significant difference in recurrence rate between the two groups at 3 and 6 months after the intervention(P>0.05).However,co

关 键 词：口炎清颗粒 康复新液 复发性口腔溃疡 临床研究 炎症水平 复发率 

分 类 号：R276.8[医药卫生—中医五官科学]