癌症患者居家口服化疗药物暴露预防及管理的最佳证据总结  

Summary of best evidence for prevention and management of oral chemotherapy drugs exposure in cancer patients at home

作　　者：刘艳[1] 温晓萌[2] 张小丫 韩小云[3] 徐春兰[1] Liu Yan;Wen Xiaomeng;Zhang Xiaoya;Han Xiao yun;Xu Chunlan(Changzhou First People′s Hospital,Changzhou 213000,China)

机构地区：[1]常州市第一人民医院肿瘤科,江苏常州213000 [2]常州市第一人民医院手术室,江苏常州213000 [3]常州市第一人民医院护理部,江苏常州213000

出　　处：《护理学杂志》2025年第4期92-96,110,共6页Journal of Nursing Science

基　　金：常州市第一人民医院循证护理项目(202449);常州市卫健委重大科技项目(ZD202312)。

摘　　要：目的对癌症患者居家口服化疗药物暴露预防及管理的相关证据进行提取和汇总,为降低癌症患者居家口服化疗药物的暴露提供循证依据。方法计算机检索临床决策网站、指南网站、专业协会网站及综合数据库中关于癌症患者居家口服化疗药物暴露预防及管理的文献,文献类型包括指南、专家共识、证据总结、系统评价,检索时限为建库至2024年3月。结果共纳入19篇文献,其中指南2篇、专家共识14篇、系统评价1篇、证据总结2篇,通过阅读、提取、归类最终形成28条最佳证据,包括组织与监管、评估与教育、药物储存与处置、服药方法、清洁与消毒、依从性管理6个方面。结论该研究总结了癌症患者居家口服化疗药物暴露预防及管理的最佳证据,临床医护人员可根据实际情境对证据进行实施,推动循证知识向实践转化。Objective To extract and summarize relevant evidence on the prevention and management of oral chemotherapy drug exposure in cancer patients at home,and to provide evidence-based recommendations for reducing oral chemotherapy drugs exposure.Methods Literature was researched on clinical decision-making websites,guideline websites,professional association websites,and comprehensive databases for articles on the prevention and management of exposure to oral chemotherapy drugs in cancer patients at home.The types of literature included guidelines,expert consensus,evidence summaries,systematic reviews,and meta-analyses,with a search timeframe from database inception to March 2024.Results A total of 19 articles were included,consisting of 2 guidelines,14 expert consensus statements,1 systematic review,and 2 evidence summaries.Through reading,extraction,and classification,28 best evidence statements were generated,covering 6 aspects including organization and regulation,assessment and education,drug storage and disposal,administration methods,cleaning and disinfection,and compliance management.Conclusion This study summarized the best evidence for the prevention and management of exposure to oral chemotherapy drugs in cancer patients at home,allowing clinical healthcare professionals to implement evidence-based practices based on actual situations and promote the translation of evidence-based knowledge into practice.

关 键 词：癌症患者 居家 口服化疗药物 暴露 预防 证据总结 循证护理 

分 类 号：R473.73[医药卫生—护理学] R473.2[医药卫生—临床医学]