脑源性神经营养因子与皮肤病  

Brain-derived neurotrophic factor and skin diseases

作　　者：李安琪 孙秋宁[1] Li Anqi;Sun Qiuning(Department of Dermatology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院皮肤科,北京100730

出　　处：《中华皮肤科杂志》2025年第2期190-193,共4页Chinese Journal of Dermatology

基　　金：北京协和医院沉淀整合基金(ZC201902245)。

摘　　要：脑源性神经营养因子作为一种参与神经元存活、生长和分化的蛋白质,在许多神经、精神相关疾病的病理生理过程中发挥重要作用。近年来脑源性神经营养因子在调节免疫、参与炎症反应等神经系统以外的功能被广泛关注,且越来越多的研究表明脑源性神经营养因子在特应性皮炎、结缔组织病和皮肤肿瘤等多种皮肤病中发挥重要作用。本文综述脑源性神经营养因子在相关皮肤病中的研究进展。Brain-derived neurotrophic factor(BDNF),a protein involved in the survival,growth and maintenance of neurons,plays an important role in pathophysiological processes in various neuropsychiatric diseases.In recent years,attention has been widely paid to the roles of BDNF in regulating immunity and participating in inflammatory reactions in non-nervous systems,and more and more studies have shown that BDNF plays an important role in various skin diseases,such as atopic dermatitis,connective tissue diseases and skin tumors.This review summarizes research advances in the role of BDNF in relevant skin diseases.

关 键 词：皮炎 特应性 皮肤肿瘤 神经痛 结缔组织疾病 脑源性神经营养因子 

分 类 号：R73[医药卫生—肿瘤]