细胞外囊泡在糖尿病肾病细胞间与器官间的通信作用  

Role of extracellular vesicles in intercellular and interorgan communication in diabetic nephropathy

作　　者：兰琴 龙红燕 达静静[2] 余福勋 查艳 Lan Qin;Long Hongyan;Da Jingjing;Yu Fuxun;Zha Yan(Graduate School of Zunyi Medical University,Zunyi 563099,China;Department of Nephrology,Guizhou Provincial People's Hospital,Guiyang 550002,China;NHC Key Laboratory of Pulmonary Immunological Disease,Guiyang 550002,China)

机构地区：[1]遵义医科大学研究生院,遵义563099 [2]贵州省人民医院肾内科,贵阳550002 [3]国家卫生健康委员会肺脏免疫性疾病诊治重点实验室,贵阳550002

出　　处：《中华肾脏病杂志》2024年第12期984-989,共6页Chinese Journal of Nephrology

基　　金：国家自然科学基金(82360148、82400851);贵州省高层次创新人才项目(黔科合平台人才[2018]5636-2);贵州省科技成果转化重大专项(黔科合成果[2023]重大010)。

摘　　要：细胞外囊泡(extracellular vesicles,EVs)为一类参与细胞间及器官间通信的载体,在肾脏疾病的发病机制、诊断和治疗中展现出了新的应用潜能。该文通过综述EVs的生物学特性、EVs介导糖尿病肾病中的器官⁃器官间串扰、细胞⁃细胞间串扰、EVs在肾脏疾病诊断与治疗中的作用,阐述EVs在糖尿病肾病细胞间与器官间的通信作用,为更全面理解EVs在糖尿病肾病发病及疾病进展中的作用提供了理论依据。Extracellular vesicles(EVs)are communication vectors between cells and organs,which have been demonstrated new potential role in the pathogenesis,diagnosis,and treatment of kidney diseases.This paper describes the role of EVs in intercellular and inter organ communication in diabetic nephropathy by reviewing the biological properties of EVs,EVs-mediated organ-organ crosstalk,cell-cell crosstalk in diabetic nephropathy,and the role of EVs in the diagnosis and treatment of renal diseases.These insights aim to provide a theoretical basis for a more comprehensive understanding of the role of EVs in the pathogenesis and progression of diabetic nephropathy.

关 键 词：细胞外囊泡 糖尿病肾病 细胞间串扰 器官间串扰 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]