益气祛白颗粒联合毫火针治疗稳定期非节段性白癜风的临床疗效及机制研究  

Clinical efficacy and mechanism of Yiqi Qubai Granules combined with filiform-fire needle therapy in treating stable non-segmental vitiligo

作　　者：谭希 陈连军 伍洲炜[1] 聂舒 陈彬 李霞[3] 宋瑜[4] TAN Xi;CHEN Lianjun;WU Zhouwei;NIE Shu;CHEN Bin;LI Xia;SONG Yu(Department of Dermatology,Shanghai General Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China;Department of Dermatology,Huashan Hospital Affiliated to Fudan University,Shanghai 200040,China;Department of Dermatology,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Department of Dermatology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海交通大学医学院附属第一人民医院皮肤科,上海200080 [2]复旦大学附属华山医院皮肤科,上海200040 [3]上海交通大学医学院附属瑞金医院皮肤科,上海200025 [4]上海中医药大学附属龙华医院皮肤科,上海200032

出　　处：《上海中医药杂志》2025年第3期61-63,93,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市科委科技计划项目(23Y31920300)。

摘　　要：目的观察口服益气祛白颗粒联合外用毫火针治疗稳定期非节段性白癜风的临床疗效。方法将62例稳定期非节段性白癜风患者随机分为试验组32例、对照组30例。对照组口服益气祛白颗粒,试验组在对照组基础上联合局部毫火针治疗,两组疗程均为12周。观察临床疗效,比较治疗前后皮肤病生活质量指数(DLQI)评分、抑郁症筛查量表(PHQ-9)评分以及外周血C-X-C基序趋化因子10(CXCL10)表达水平的变化情况。结果①试验组、对照组临床总显效率分别为43.8%、26.7%,白斑复色率分别为(49.8±27.7)%、(34.8±24.4)%,差异均有统计学意义(P<0.05)。②治疗前后组内比较,两组DLQI评分均有所降低(P<0.05),试验组PHQ-9评分下降(P<0.05),对照组PHQ-9评分下降,但无统计学意义(P>0.05)。③治疗前后组内比较,两组外周血CXCL10表达水平均下降(P<0.05);组间治疗后比较,试验组CXCL10表达水平低于对照组(P<0.05)。结论益气祛白颗粒联合毫火针治疗稳定期非节段性白癜风,能够有效促进白斑复色,提升患者生活质量,并减轻其抑郁症状。Objective To observe the clinical efficacy of Yiqi Qubai Granules(oral intake)combined with filiform-fire needle therapy in treating stable non-segmental vitiligo.Methods A total of 62 patients with stable non-segmental vitiligo were randomly divided into an experimental group(n=32)and a control group(n=30).Patients in both groups were treated with Yiqi Qubai Granules orally,and those in the experimental group additionally received localized treatment with filiform-fire needle therapy.The treatment lasted for 12 weeks.Clinical efficacy was observed,and changes in the scores of Dermatology Life Quality Index(DLQI)and Patient Health Questionnaire(PHQ-9),as well as in the peripheral blood C-X-C motif chemokine ligand 10(CXCL10)expression level,were compared before and after treatment.Results①The total clinical effective rate was 43.8%in the experimental group and 26.7%in the control group,while the repigmentation rates were(49.8±27.7)%and(34.8±24.4)%in the two groups,respectively.The differences were statistically significant(P<0.05).②Intra-group comparisons before and after treatment showed a significant reduction in DLQI scores for both groups(P<0.05).In the experimental group,the PHQ-9 score decreased significantly(P<0.05),while in the control group,the decrease in PHQ-9 score was not statistically significant(P>0.05).③Intra-group comparisons before and after treatment showed a significant decrease in peripheral blood CXCL10 expression level in both groups(P<0.05).Inter-group comparisons after treatment revealed that the CXCL10 expression level was significantly lower in the experimental group than in the control group(P<0.05).Conclusion The combination of Yiqi Qubai Granules and filiform-fire needle therapy is effective in promoting repigmentation,improving patients'quality of life,and alleviating depressive symptoms in stable non-segmental vitiligo patients.

关 键 词：白癜风 中药 针灸 毫火针 抑郁 生活质量 临床试验 

分 类 号：R275.9[医药卫生—中西医结合]