土家药山姜挥发油对小鼠胃肠动力的影响  

Effects of Volatile Oil of the Alpinia japonica Rhizome on Gastrointestinal Motility of Mice in Tujia Medicine

作　　者：赵京 许太静 罗静 彭清波 高志宏 向娟[1,2,3] ZHAO Jing;XU Taijing;LUO Jing;PENG Qingbo;GAO Zhihong;XIANG Juan(Chemical and Pharmacological Laboratory of Medicinal Resources in Wuling Mountain Area,College of Pharmaceutical Sciences,Jishou University,Jishou 416000,Hunan China;State Ethnic Affairs Commission Key Laboratory for the Inheritance and Innovation of Tujia Medicine,Jishou 416000,Hunan China;Tujia Medicine Research Center in Hunan,Jishou 416000,Hunan China)

机构地区：[1]吉首大学药学院武陵山区药用资源化学与药理湖南省高校重点实验室,湖南吉首416000 [2]土家医药传承与创新实验室国家民委重点实验室,湖南吉首416000 [3]湖南省土家医药研究中心,湖南吉首416000

出　　处：《吉首大学学报(自然科学版)》2024年第6期11-15,共5页Journal of Jishou University(Natural Sciences Edition)

基　　金：湖南省自然科学基金资助项目(2021JJ40442);湖南省教育厅科学研究项目(20C1517);大学生创新训练计划项目(JDCX2023946)。

摘　　要：将小鼠分为对照组、大黄组、山姜挥发油5.2 g/kg剂量组、山姜挥发油10.4 g/kg剂量组,通过肠推进试验、排便观察、胃排空试验等探究山姜根茎中的挥发油成分对小鼠肠道推进功能、排便功能、胃排空功能的影响.结果表明,与对照组相比,大黄组、山姜挥发油5.2 g/kg剂量组、山姜挥发油10.4 g/kg剂量组的肠道炭末推进率均有所升高;与对照组相比,大黄组、山姜挥发油5.2 g/kg剂量组、山姜挥发油10.4 g/kg剂量组的首次排黑便时间均有所提前;与对照组相比,大黄组、山姜挥发油5.2 g/kg剂量组、山姜挥发油10.4 g/kg剂量组的胃排空率均有所升高;山姜挥发油10.4 g/kg剂量组的提升作用与大黄组的提升作用相当.这提示山姜挥发油对小鼠的肠推进、排便、胃排空均具有一定的促进作用.To investigate the effects of volatile oil of the Alpinia japonica rhizome on the gastrointestinal motility of mice,mice were divided into control group,rhubarb group,volatile oil of the Alpinia japonica rhizome 5.2 g/kg dose group,and volatile oil of the Alpinia japonica rhizome 10.4 g/kg dose group.The effects of volatile oil of the Alpinia japonica rhizome on the intestinal propulsion function,defecation function,and gastric emptying function of mice were explored through intestinal propulsion test,defecation observation,and gastric emptying test.The results showed that the charcoal retention rate of the rhubarb group,volatile oil of the Alpinia japonica rhizome 5.2 g/kg dose group,and volatile oil of the Alpinia japonica rhizome 10.4 g/kg dose group was all higher than that of the control group;the first black defecation time of the rhubarb group,volatile oil of the Alpinia japonica rhizome 5.2 g/kg dose group,and volatile oil of the Alpinia japonica rhizome 10.4 g/kg dose group was all earlier than that of the control group;the gastric emptying rate of the rhubarb group,volatile oil of the Alpinia japonica rhizome 5.2 g/kg dose group,and volatile oil of the Alpinia japonica rhizome 10.4 g/kg dose group was all higher than that of the control group;the enhancement effect of volatile oil of the Alpinia japonica rhizome 10.4 g/kg dose group was comparable to that of the rhubarb group.The results suggest that volatile oil of the Alpinia japonica rhizome has certain promoting effects on the intestinal propulsion,defecation,and gastric emptying of mice.

关 键 词：山姜 挥发油 胃肠动力 肠推进 排便 胃排空 

分 类 号：R29[医药卫生—民族医学]