加味葛根芩连汤联合针刺对大肠湿热型溃疡性结肠炎患者的临床疗效  

Clinical effects of Supplemented Gegen Qinlian Decoction combined with acupuncture on patients with ulcerative colitis of Large Intestinnal Dampness-heat Pattern

作　　者：陈天 王泽惠 彭云花[1] 王清园 裴艳妮 羊琪琪 杨巍[1] CHEN Tian;WANG Ze-hui;PENG Yun-hua;WANG Qing-yuan;PEI Yan-ni;YANG Qi-qi;YANG Wei(Department of Proctology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院肛肠科,上海201203

出　　处：《中成药》2025年第2期453-457,共5页Chinese Traditional Patent Medicine

基　　金：上海市临床重点专科项目(shslczdzk04302);上海市科学技术委员会项目(20Y21901000);上海市卫生健康委员会项目(20204Y0180);杨巍全国名老中医药专家传承工作室(2022);上海中医药大学预算内项目(2021LK083)。

摘　　要：目的考察加味葛根芩连汤联合针刺对大肠湿热型溃疡性结肠炎患者的临床疗效。方法120例患者随机分为对照组和观察组,每组60例,对照组给予培菲康胶囊及美沙拉嗪缓释颗粒,观察组在对照组基础上加用加味葛根芩连汤联合针刺,疗程1个月。检测临床疗效、症状缓解时间、中医证候评分、Geboes指数、病变活动指数、Baron评分、炎症因子(IL-6、IL-8、TNF-α)、免疫功能指标(IgA、IgG、IgM)、IBDQ评分、复发率变化。结果观察组总有效率高于对照组(P<0.05),症状缓解时间更短(P<0.05),复发率更低(P<0.05)。治疗后,2组中医证候评分、Geboes指数、病变活动指数、Baron评分、炎症因子、IgG、IgM降低(P<0.05),IBDQ评分升高(P<0.05),以观察组更明显(P<0.05)。结论加味葛根芩连汤联合针刺可改善大肠湿热型溃疡性结肠炎患者临床症状,促进病情恢复,提高免疫功能与生活质量,降低复发率。AIM To investigate the clinical effects of Supplemented Gegen Qinlian Decoction combined with acupuncture on patients with ulcerative colitis of Large Intestinal Dampness-heat Pattern.METHODS One hundred and twenty patients were randomly assigned into control group(60 cases)for 1-month administration of Pefikang Capsules and Mesalazine Sustained Release Granules,and observation group(60 cases)for 1-month administration of Supplemented Gegen Qinlian Decoction,acupuncture,Pefikang Capsules and Mesalazine Sustained Release Granules.The changes in clinical effects,symptom remission time,TCM syndrome scores,Geboes index,lesion activity index,Baron score,inflammatory factors(IL-6,IL-8,TNF-α),immune function indices(IgA,IgG,IgM),IBDQ score and recurrence rate were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05),along with shorter symptom remission time(P<0.05)and lower recurrence rate(P<0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,Geboes index,lesion activity index,Baron score,inflammatory factors,IgG,IgM(P<0.05),and increased IBDQ score(P<0.05),especially for the observation group(P<0.05).CONCLUSION For the patients with ulcerative colitis of Large Intestinal Dampness-heat Pattern,Gegen Qinlian Decoction combined with acupuncture can improve clinical symptoms,promote disease recovery,enhance immune functions and life quality,and reduce recurrence rate.

关 键 词：加味葛根芩连汤 针刺 培菲康胶囊 美沙拉嗪缓释颗粒 溃疡性结肠炎 大肠湿热 免疫功能 生活质量 

分 类 号：R287[医药卫生—中药学]