通腑排气合剂内服、灌肠对慢性阻塞性肺疾病急性加重期伴胃肠功能障碍患者的临床疗效  

Clinical effects of oral administration and enema of Tongfu Paiqi Mixture on patients with acute exacerbation of chronic obstructive pulmonary disease complicated with gastrointestinal dysfunction

作　　者：毛莉娜 谢沛霖 黄莺 杨硕 MAO Li-na;XIE Pei-lin;HUANG Ying;YANG Shuo(Wuhan Municipal Hospital of Integrated Traditional Chinese and Western Medicine(The First Hospital of Wuhan),Wuhan 430022,China)

机构地区：[1]武汉市中西医结合医院(武汉市第一医院),湖北武汉430022

出　　处：《中成药》2025年第2期457-462,共6页Chinese Traditional Patent Medicine

基　　金：国家中医药管理局全国名老中医药专家传承工作室建设项目(2017);湖北省公共卫生青年拔尖人才计划项目(鄂卫2021-74);武汉市卫生和计划生育委员会科研项目(WZ17A02)。

摘　　要：目的探讨通腑排气合剂内服、灌肠对慢性阻塞性肺疾病急性加重期伴胃肠功能障碍患者的临床疗效。方法108例患者随机分为对照组和观察组,每组54例,2组采用常规治疗,同时对照组给予通腑排气合剂模拟药内服、灌肠,观察组给予通腑排气合剂内服、灌肠,疗程5 d。检测临床疗效、GIDS评分、痰瘀阻肺证评分、胃肠黏膜屏障血清标志物(DAO、D-LA、IFABP)、腹内压、胃肠激素(MTL、GAS、VIP)、炎症因子(IL-1β、IL-6、TNF-α、PCT)、肺功能指标(FEV 1、FEV 1%)、PaO_(2)/FiO_(2)变化。结果观察组总有效率高于对照组(P<0.05)。治疗后,2组GIDS评分、痰瘀阻肺证评分、腹内压、VIP、胃肠黏膜屏障血清标志物、炎症因子降低(P<0.05),MTL、GAS、肺功能指标、PaO_(2)/FiO_(2)升高(P<0.05),以观察组更明显(P<0.05)。结论通腑排气合剂内服、灌肠可调节慢性阻塞性肺疾病急性加重期伴胃肠功能障碍患者胃肠激素,减轻炎症程度,保护肠屏障功能,缓解临床症状,改善肺功能。AIM To explore the clinical effects of oral administration and enema of Tongfu Paiqi Mixture on patients with acute exacerbation of chronic obstructive pulmonary disease complicated with gastrointestinal dysfunction.METHODS One hundred and eight patients were randomly assigned into control group(54 cases)for 5-day intervention of both oral administration and enema of Tongfu Paiqi Mixture simulant and conventional treatment,and observation group(54 cases)for 5-day intervention of both oral administration and enema of Tongfu Paiqi Mixture and conventional treatment.The changes in clinical effects,GIDS score,Phlegm and Blood Stasis Obstructing Lung Syndrome score,gastrointestinal mucosal barrier serum markers(DAO,D-LA,IFABP),intra-abdominal pressure,gastrointestinal hormones(MTL,GAS,VIP),inflammatory factors(IL-1β,IL-6,TNF-α,PCT),pulmonary function indices(FEV 1、FEV 1%)and PaO_(2)/FiO_(2) were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed decreased GIDS score,Phlegm and Blood Stasis Obstructing Lung Syndrome score,intra-abdominal pressure,VIP,gastrointestinal mucosal barrier serum markers,inflammatory factors(P<0.05),and increased MTL,GAS,pulmonary function indices,PaO_(2)/FiO_(2)(P<0.05),especially for the observation group(P<0.05).CONCLUSION For the patients with acute exacerbation of chronic obstructive pulmonary disease complicated with gastrointestinal dysfunction,the oral administration and enema of Tongfu Paiqi Mixture can regulate gastrointestinal hormones,reduce inflammatory degree,protect intestinal barrier functions,alleviate clinical symptoms,and improve pulmonary functions.

关 键 词：通腑排气合剂 内服 灌肠 常规治疗 慢性阻塞性肺疾病急性加重期 胃肠功能障碍 胃肠激素 炎症因子 

分 类 号：R287[医药卫生—中药学]