应用虚拟组织学血管内超声探讨血小板/淋巴细胞比值水平与冠心病合并2型糖尿病患者冠状动脉斑块特点的关系  

Study on the relationship between platelet/lymphocyte ratio and coronary plaque characteristics in coronary heart disease patients combined with type 2 diabetes mellitus by virtual histology intravascular ultrasound

作　　者：胡松林 邸雅 刘灿章 闫杰 Hu Songlin;Di Ya;Liu Canzhang;Yan Jie(Ward 1,Department of Cardiovascular Medicine,North China University of Science andTechnology Affiliated Hospital,Tangshan 063000,China)

机构地区：[1]华北理工大学附属医院心血管内科一病区,河北唐山063000

出　　处：《临床荟萃》2025年第2期117-121,共5页Clinical Focus

基　　金：河北省财政厅、河北省卫生健康委资助项目——血管内超声斑块成分特征结合血清mir-208b及FT3对冠状动脉斑块稳定性及预后的预测价值研究(ZF2024197)。

摘　　要：目的应用虚拟组织学血管内超声(VH-IVUS)探讨血小板/淋巴细胞比值(PLT/LYM,PLR)与冠心病合(CHD)并2型糖尿病(T2DM)患者冠状动脉斑块特点的关系。方法选取2023年3月-2024年3月于华北理工大学附属医院心血管内科一病区住院患者,同时接受了冠状动脉介入治疗(PCI)以及虚拟组织学血管内超声(VH-IVUS)检查的CHD合并T2DM的患者86例。根据患者的PLR中位数水平分为两组:高PLR水平组(n=43)和低PLR水平组(n=43)。通过VH-IVUS检查,探讨PLR与CHD合并T2DM患者冠状动脉斑块特点的关系。结果全部患者血液指标中PLR水平为37.22~331.76,中位数为119.22,其中低PLR组斑块面积、外弹力膜面积、坏死核心组织容积比例、纤维脂肪组织容积比例、斑块负荷、斑块总容积均低于高PLR组,差异具有统计学意义(P<0.05);Pearson相关分析显示:PLR与斑块面积(r=0.398,P=0.000)、外弹力膜面积(r=0.299,P=0.005)、斑块负荷(r=0.338,P=0.001)、斑块总容积(r=0.263,P=0.014)呈正相关。结论PLR水平可作为一项判断斑块面积及斑块容积的一项研究指标。Objective The relationship between platelet/lymphocyte ratio(PLT/LYM,PLR)and the characteristics of coronary plaque in coronary heart disease(CHD)patients combined with type 2 diabetes mellitus(T2DM)was studied by virtual histology intravascular ultrasound(VH-IVUS).Methods A total of 86 CHD patients combined with T2DM who were hospitalized in the First Ward of the Cardiovascular Department of the Affiliated Hospital of North China University of Science and Technology from March 2023 to March 2024 and underwent coronary intervention therapy(PCI)and intravascular ultrasound(VH-IVUS)examination were recruited.The patients were divided into two groups based on the median PLR levels:high PLR group(n=43)and low PLR group(n=43).The relationship between PLR and coronary plaque characteristics in CHD patients combined with T2DM was explored by VH-IVUS.Results Blood PLR levels in all patients ranged from 37.22 to 331.76,with a median of 119.22.The plaque area,outer elastic membrane area,necrotic tissue volume ratio,adipose tissue volume ratio,plaque burden,and total plaque volume in the low PLR group were all significantly lower than those in the high PLR group(P<0.05).Pearson correlation analysis showed that plaque area(r=0.398,P=0.000),outer elastic membrane area(r=0.299,P=0.005),plaque load(r=0338,P=0.001),and total plaque volume(r=0.263,P=0.014)were positively correlated with PLR.Conclusion PLR level can be used as a study index to determine plaque area and plaque volume.

关 键 词：冠心病 糖尿病 2型 血小板 淋巴细胞 超声检查 介入性 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]