炎症因子在糖尿病性心肌病病程中的作用与临床意义  

The Role and Clinical Significance of Inflammatory Factors in the Course of Diabetes Cardiomyopathy

作　　者：杨贺然 陈萌 李彦伟 梁秀娥 张怡扬 李兴江 Heran Yang;Meng Chen;Yanwei Li;Xiue Liang;Yiyang Zhang;Xingjiang Li(Laboratory Department of Hongqi Hospital Affiliated to Mudanjiang Medical University,Mudanjiang,Heilongjiang 157000;Anesthesiology Department of Hongqi Hospital Affiliated to Mudanjiang Medical University,Mudanjiang,Heilongjiang 157000;Obstetrics and Gynecology Department of Mudanjiang Maternal and Child Health Hospital,Mudanjiang,Heilongjiang 157000;School of Basic Medicine,Mudanjiang Medical University,Mudanjiang,Heilongjiang 157000;School of Life Sciences,Mudanjiang Medical University,Mudanjiang,Heilongjiang 157000)

机构地区：[1]牡丹江医科大学附属红旗医院检验科,黑龙江牡丹江157000 [2]牡丹江医科大学附属红旗医院麻醉科,黑龙江牡丹江157000 [3]牡丹江市妇幼保健院妇产科,黑龙江牡丹江157000 [4]牡丹江医科大学基础医学院,黑龙江牡丹江157000 [5]牡丹江医科大学生命科学学院,黑龙江牡丹江157000

出　　处：《医学研究前沿》2024年第11期20-22,共3页Frontiers of Medical Research

基　　金：2024年黑龙江省自然科学基金项目(PL2024H204):ABCA1通过mTOR通路介导糖尿病心肌病心肌自噬的机制研究;2024年度黑龙江省属高等学校基本科研业务费科研项目(2024-KYYWF-0471):EZH2介导糖尿病心肌病心肌细胞自噬的机制研究;2024年度黑龙江省属高等学校基本科研业务费科研项目(2024-KYYWF-0460):SIX4诱SMD4缺失突变胰腺癌吉西他滨耐药的机制研究。

摘　　要：目的本次研究为了分析炎症因子在糖尿病性心肌病病程中的具体作用,并探讨其临床意义。方法本次研究选择了2023年4月到2024年4月在我院接受治疗的30名糖尿病性心肌病患者,根据患者白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的高低划分为,炎症因子较低的实验组和炎症因子较高的对照组,对比两组患者对比两组治疗前后相关指标,主要包括LVEDD、LVESD、LVEDV、LVESV、LVEF等指标;比较两组治疗前后血糖水平,包括HbAlc、FBG与2hPG等。结果实验组LVEDD、LVESD、LVEDV、LVESV、LVEF等指标均比对照组优,差异有统计学意义(P<0.05)。两组患者组内治疗前后HbAlc、FBG与2hPG水平降低,差异有统计学意义(P<0.05);对比两组HbAlc、FBG与2hPG水平,差异无统计学意义(P>0.05)。结论炎症因子在糖尿病性心肌病病程中的作用不容忽视,其不仅与心脏重构密切相关,还可能影响到疾病的治疗效果和预后。因此,未来的研究应进一步深入探讨炎症因子的具体作用机制,并探索有效的干预策略,以期为患者提供更加精准和全面的治疗。Objective To analyze the specific role of inflammatory factors in the course of diabetes cardiomyopathy and explore its clinical significance.Method In this study,30 patients with diabetes cardiomyopathy who were treated in our hospital from April 2023 to April 2024 were selected.According to the level of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α),the patients were divided into the experimental group with lower inflammatory factors and the control group with higher inflammatory factors.The two groups of patients were compared with the relevant indicators before and after treatment,mainly including LVEDD,LVESD,LVEDV,LVESV,LVEF and other indicators;Compare the blood glucose levels before and after treatment between two groups,including HbAlc,FBG,and 2hPG.Result LVEDD,LVESD,LVEDV,LVESV,LVEF and other indicators in the experimental group were better than those in the control group,and the differences were statistically significant(P<0.05).The levels of HbAlc,FBG,and 2hPG in both groups of patients decreased significantly before and after treatment(P<0.05);There was no statistically significant difference in the levels of HbAlc,FBG,and 2hPG between the two groups(P>0.05).Conclusion the role of inflammatory factors in the course of diabetes cardiomyopathy cannot be ignored.It is not only closely related to cardiac remodeling,but also may affect the therapeutic effect and prognosis of the disease.Therefore,future research should further explore the specific mechanisms of action of inflammatory factors and explore effective intervention strategies in order to provide more precise and comprehensive treatment for patients.

关 键 词：炎症因子 糖尿病性心肌病 作用 临床意义 

分 类 号：R587.2[医药卫生—内分泌]