HBV感染与线粒体稳态相互作用的分子机制  

Molecular mechanisms of the interaction between hepatitis B virus infection and mitochondrial homeostasis

作　　者：李兴统 周太成[1] LI Xingtong;ZHOU Taicheng(Department of Central Laboratory,Affiliated Hospital of Yunnan University,Kunming 650021,China)

机构地区：[1]云南大学附属医院中心实验室,昆明650021

出　　处：《临床肝胆病杂志》2025年第2期343-348,共6页Journal of Clinical Hepatology

基　　金：云南省科技厅-昆明医科大学运用基础联合专项面上项目(202101AY070001-283);云南省高层次科技人才及创新团队选拔专项(202205AC160023)。

摘　　要：HBV感染可造成急性或慢性感染,未经治疗的患者可发展为肝硬化、肝癌而死亡。线粒体作为重要的细胞器之一,其正常形态和功能的维持是保证细胞进行各种生理活动的主要基础,线粒体动力学、线粒体自噬、损伤、氧化磷酸化等生理活动均可影响线粒体稳态的维持。HBV感染可影响线粒体稳态,本文从线粒体动力学、线粒体自噬、线粒体氧化磷酸化及线粒体损伤4个方面总结线粒体稳态与HBV感染的研究进展,深入探讨线粒体稳态的维持与HBV感染的关系,以期为理解HBV感染的分子机制,甚至寻找HBV潜在治疗靶点提供一定的理论依据。Hepatitis B virus(HBV)infection can cause acute or chronic infection,while untreated patients can develop into liver cirrhosis or liver cancer,thereby leading to death.As one of the most important organelles of cells,the maintenance of the normal morphology and function of mitochondria is the basis for ensuring various physiological activities in cells,and physiological activities,such as mitochondrial dynamics,mitophagy,injury,and oxidative phosphorylation,can affect the maintenance of mitochondrial homeostasis.HBV infection can affect mitochondrial homeostasis.This article summarizes the research advances in mitochondrial homeostasis and HBV infection from the four aspects of mitochondrial dynamics,mitophagy,mitochondrial oxidative phosphorylation,and mitochondrial injury and discusses the association between the maintenance of mitochondrial homeostasis and HBV infection,in order to provide a theoretical basis for understanding the molecular mechanism of HBV infection and identifying the potential therapeutic targets for HBV.

关 键 词：乙型肝炎病毒 线粒体 线粒体动力学 线粒体自噬 氧化磷酸化 

分 类 号：R512.62[医药卫生—内科学]