中药调控免疫细胞治疗肝细胞癌的研究进展  

Research advances in traditional Chinese medicine for the treatment of hepatocellular carcinoma by regulating immune cells

作　　者：龙丽娟 王宗玉 赵雅丽 覃川福 邱华 LONG Lijuan;WANG Zongyu;ZHAO Yali;QIN Chuanfu;QIU Hua(The First Clinical Medical College of Guangxi Medical University,Nanning 530021,China;Department of Traditional Chinese Medicine,Guangxi Medical University Cancer Hospital,Nanning 530021,China;School of Oncology,Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学第一临床医学院,南宁530021 [2]广西医科大学附属肿瘤医院中医科,南宁530021 [3]广西医科大学肿瘤医学院,南宁530021

出　　处：《临床肝胆病杂志》2025年第2期349-358,共10页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81860889);广西自然科学基金区域高发疾病研究联合专项资助(项目任务书编号:2024GXNSFAA010131,2024GXNSFBA010182);广西壮族自治区蛇资源抗肿瘤药用研发与应用工程研究中心项目(桂发改高技函〔2023〕2727号)。

摘　　要：肝细胞癌(HCC)是一种常见且死亡率较高的恶性肿瘤,其起病隐匿,病理机制复杂。在肿瘤微环境中,促肿瘤免疫细胞保护肿瘤细胞免受免疫攻击,抗肿瘤免疫细胞发生功能障碍使免疫反应被抑制,最终导致癌症持续恶化。近年来中医药在治疗HCC方面显示出良好的疗效,中药能够调控免疫细胞进而抑制癌细胞增殖与转移。本文通过分析汇总近年来国内外相关文献,总结免疫细胞如何通过免疫抑制途径影响HCC进展以及中药如何调控免疫细胞发挥抗HCC作用,以期为HCC治疗的优化提供理论依据与参考。Hepatocellular carcinoma(HCC)is a common malignant tumor with a high mortality rate,an insidious onset,and complex pathological mechanisms.In the tumor microenvironment,tumor-promoting immune cells protect tumor cells from immune attacks,while dysfunction of anti-tumor immune cells causes the inhibition of immune response,thereby leading to the continuous deterioration of cancer.In recent years,traditional Chinese medicine has shown good efficacy in the treatment of HCC,and it can inhibit the proliferation and metastasis of cancer cells by regulating immune cells.By analyzing related articles in China and globally,this article summarizes how immune cells affect the progression of HCC through the immunosuppressive pathway and how traditional Chinese medicine exerts an anti-HCC effect by regulating immune cells,in order to provide theoretical basis and reference for optimizing the treatment of HCC.

关 键 词：癌 肝细胞 免疫细胞 免疫抑制 中药 

分 类 号：R273[医药卫生—中西医结合]