肝性脑病中医/壮医“浊毒致病”理论及防治策略的构建与实践  

Construction and practice of the theory of“turbid toxin pathogenesis”and related prevention and treatment strategies for hepatic encephalopathy in traditional Chinese medicine/Zhuang medicine

作　　者：吴智鹏 张钰琴 姚春[1] 王明刚[1] 王娜[1] 彭梦如 磨宁芳 郑娅晴 张荣臻[1] 毛德文[1] WU Zhipeng;ZHANG Yuqin;YAO Chun;WANG Minggang;WANG Na;PENG Mengru;MO Ningfang;ZHENG Yaqing;ZHANG Rongzhen;MAO Dewen(First Ward of Hepatology,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China;School of Pre-clinical Medicine,Guangxi Medical University,Nanning 530021,China;Department of Acupuncture and Moxibustion,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]广西中医药大学第一附属医院肝病一区,南宁530023 [2]广西医科大学基础医学院,南宁530021 [3]中国中医科学院广安门医院针灸科,北京100053

出　　处：《临床肝胆病杂志》2025年第2期370-374,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(82160881,82260899);广西重点研发计划项目(桂科AB22035076);广西中医药大学“岐黄工程”高层次人才团队培育项目(202409);广西中医药大学桂派中医药传承创新团队项目(2022A001);广西中医药大学第一附属医院青年拔尖人才培养对象资助项目(院党字〔2022〕46号)。

摘　　要：肝性脑病为肝病领域的疑难危重疾病,进展迅速、治疗手段有限、发病机制亟待突破。选择合适的防治策略,对于延缓疾病进展、降低发病率和病死率起到重要作用。本文就中医/壮医肝性脑病“浊毒致病”理论及防治策略进行述评,提出肝性脑病中医/壮医“浊毒致病”新学说,解析“浊”“毒”及“浊毒致病”理论的科学内涵,构建肝性脑病“四步曲”防治策略,并以此为基础延伸出以“四方两技法”为代表的肝性脑病临床防治新方案,继而阐明核心方药与技法防治肝性脑病的效应机制与生物学基础,以期为肝性脑病的防治提供参考。Hepatic encephalopathy is a difficult and critical disease with rapid progression and limited treatment methods in the field of liver disease,and it is urgently needed to make breakthroughs in its pathogenesis.Selection of appropriate prevention and treatment strategies is of great importance in delaying disease progression and reducing the incidence and mortality rates.This article reviews the theory of“turbid toxin pathogenesis”and related prevention and treatment strategies for hepatic encephalopathy in traditional Chinese medicine/Zhuang medicine,proposes a new theory of“turbid toxin pathogenesis”,analyzes the scientific connotations of“turbid”,“toxin”,and the theory of“turbid toxin pathogenesis”,and constructs the“four-step”prevention and treatment strategies for hepatic encephalopathy,thereby establishing the new clinical prevention and treatment regimen for hepatic encephalopathy represented by“four prescriptions and two techniques”and clarifying the effect mechanism and biological basis of core prescriptions and techniques in the prevention and treatment of hepatic encephalopathy,in order to provide a reference for the prevention and treatment of hepatic encephalopathy.

关 键 词：肝性脑病 浊毒致病 治疗学 

分 类 号：R259[医药卫生—中西医结合]