中药自制剂解郁化痰安神颗粒致失眠类瞑眩反应的讨论  

Discussion on the insomnia like dizziness reaction caused by self-made traditional Chinese medicine Jieyu Huatan Anshen Granules

作　　者：李俊 张燕 董海明 杨莹 张瑞丽[4] LI Jun;ZHANG Yan;DONG Haiming;YANG Ying;ZHANG Ruili(Pharmacy Department of Zibo Integrated Traditional Chinese and Western Medicine Hospital,Zibo 255026,China;Pharmacy Department of Zhangdian District People’s Hospital in Zibo City,Zibo 255025,China;Classic Department of Zibo Integrated Traditional Chinese and Western Medicine Hospital,Zibo 255026,China;Department of Pharmacy of Wangjing Hospital of China Academy of Chinese Medical Sciences,Beijing 100102,China)

机构地区：[1]淄博市中西医结合医院药学部,山东淄博255026 [2]淄博市张店区人民医院药剂科,山东淄博255025 [3]淄博市中西医结合医院经典科,山东淄博255026 [4]中国中医科学院望京医院药学部,北京100102

出　　处：《广州医药》2025年第2期268-272,共5页Guangzhou Medical Journal

基　　金：山东省药品化妆品不良反应监测哨点课题(2023SDADRKY48)。

摘　　要：目的提示临床在使用解郁化痰安神颗粒过程中,予以关注其发生的药物不良反应,同时进一步重视中成药及中药制剂带来的药物不良反应,并与中医药当中的瞑眩反应予以区分。方法通过分析1例解郁化痰安神颗粒致失眠不良反应,基于中国知网、万方数据知识服务平台等国内数据库,对不良反应发生机制予以分析、讨论。结果本次解郁化痰安神颗粒致失眠不良反应1例,不良反应相关性评价为“可能”,根据临床观察,可能为中药中典型的“瞑眩反应”。结论临床当发现基于中成药的不良反应,应予以分析辨别,及时处置药物不良反应,进一步观察研究瞑眩反应。Objective To suggest that during the clinical use of Jieyu Huatan Anshen Granules,attention should be paid to its adverse drug reactions,and further attention should be paid to the adverse drug reactions caused by traditional Chinese patent medicines and simple preparations and traditional Chinese medicine preparations,and it should be distinguished from the insomnia and dizziness reactions in traditional Chinese medicine.Methods A case of insomnia adverse reaction caused by Jieyu Huatan Anshen Granules was analyzed based on domestic databases such as CNKI and Wanfang data to investigate and discuss the mechanism of adverse reactions.Results One case of insomnia adverse reaction caused by Jieyu Huatan Anshen Granules was reported,and the correlation evaluation of the adverse reaction was“possible”.According to clinical observations,it may be a typical“dizziness reaction”in traditional Chinese medicine.Conclusions When adverse reactions based on traditional Chinese medicine decoction,traditional Chinese patent medicines and simple preparations and other traditional Chinese medicine preparations are found in clinical practice,they should be analyzed and identified,and the adverse reactions should be handled in time and be further observed and studied.

关 键 词：解郁化痰安神颗粒 失眠 瞑眩反应 药物不良反应 

分 类 号：R256.23[医药卫生—中医内科学]