高压氧对重型颅脑损伤合并肺部感染病人血清炎性指标的影响  

Effect of hyperbaric oxygen treatment on serum inflammatory markers of patients with severe traumatic brain injury complicated with pulmonary infection

作　　者：郭博升 赵振升 闵翠丽[3] 刘许昌 常青[1] 张伟[1] GUO Bo-sheng;ZHAO Zhen-sheng;MIN Cui-li;LIU Xu-chang;CHANG Qing;ZHANG Wei(Department of Neurosurgery,Yidu Central Hospital of Weifang,Weifang 262500,China;Department of Hyperbaric Oxygen,Yidu Central Hospital of Weifang,Weifang 262500,China;Department of Laboratory Medicine,Yidu Central Hospital of Weifang,Weifang 262500,China)

机构地区：[1]山东第二医科大学附属潍坊市益都中心医院神经外科,山东青州262500 [2]山东第二医科大学附属潍坊市益都中心医院高压氧科,山东青州262500 [3]山东第二医科大学附属潍坊市益都中心医院检验科,山东青州262500

出　　处：《中国临床神经外科杂志》2024年第10期590-594,598,共6页Chinese Journal of Clinical Neurosurgery

基　　金：潍坊市卫健委科研项目计划(WFSWJK-2020-308)。

摘　　要：目的观察高压氧(HBO)治疗对重型颅脑损伤合并肺部感染病人血清C反应蛋白(CRP)、降钙素原(PCT)、内毒素等炎性指标的影响。方法2020年6月至2022年3月前瞻性收集重度颅脑损伤合并肺部感染60例,分为对照组与观察组,每组30例。对照组行降低颅内压、应用抗生素等常规治疗,观察组在对照组治疗的基础上加用高压氧治疗。比较两组病人治疗前、治疗后1~6周血清CRP、PCT、内毒素水平。结果治疗前,两组病人血清CRP、PCT、内毒素水平均无统计学差异(P>0.05)。治疗后1~6周,两组三项血清炎性指标均明显下降(P<0.05),而且观察组明显低于对照组(P<0.05)。结论HBO治疗可快速降低重度颅脑损伤合并肺部感染病人血清CRP、PCT、内毒素等指标,这提示联合监测三个指标可指导病人的治疗。Objective To explore the effect of hyperbaric oxygen(HBO)treatment on inflammatory markers including serum Creactive protein(CRP),procalcitonin(PCT),and endotoxin in patients with severe traumatic brain injury(sTBI)complicated with pulmonary infection.Methods From June 2020 to March 2022,60 patients with sTBI combined with pulmonary infection were prospectively collected and divided into a control group and an observation group,with 30 cases in each group.The control group received conventional treatments such as reducing intracranial pressure and applying antibiotics,while the observation group received HBO therapy in addition to the treatment of the control group.The levels of serum CRP,PCT,and endotoxin in the two groups were compared before treatment and 1 to 6 weeks after treatment.Results Before treatment,there was no statistically significant difference in the levels of serum CRP,PCT,and endotoxin between the two groups(P>0.05).From 1 to 6 weeks after treatment,the three serum inflammatory markers in both groups decreased significantly(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05).Conclusion HBO treatment can rapidly reduce the levels of serum CRP,PCT,and endotoxin in patients with sTBI complicated with pulmonary infection,suggesting that combined monitoring of these three indicators can guide the treatment of patients with sTBI complicated with pulmonary infection.

关 键 词：重型颅脑损伤 肺部感染 高压氧 血清 C-反应蛋白 降钙素原 内毒素 

分 类 号：R651.15[医药卫生—外科学]