lncRNA在颅脑损伤中作用机制的研究进展  

Research progress on the mechanism of lncRNA in traumatic brain injury

作　　者：赵小云 胡博玄 刘子华 刘红朝 ZHAO Xiao-yun;HU Bo-xuan;LIU Zi-hua;LIU Hong-chao(Hubei University of Traditional Chinese Medicine,Wuhan 430000,China;Department of Neurosurgery,Xinhua Hospital Affiliated to Hubei University of Traditional Chinese Medicine/Hubei Provincial Hospital of Integrated Traditional and Western Medicine,Wuhan 430015,China)

机构地区：[1]湖北中医药大学,武汉430000 [2]湖北中医药大学附属新华医院/湖北省中西医结合医院神经外科,武汉430015

出　　处：《中国临床神经外科杂志》2024年第10期624-628,共5页Chinese Journal of Clinical Neurosurgery

基　　金：湖北省卫生健康委科研项目(jx4b42)。

摘　　要：颅脑损伤(TBI)是最常见的获得性脑损伤,具有病情复杂、致残率和病死率高、生活质量差与经济负担重等特点。早期、快速、准确地诊断TBI对积极有效指导临床治疗和判断预后起到至关重要的作用。近年来,研究发现长链非编码RNA(lncRNA)在TBI中发挥着多种生物学作用,能够作为TBI早期诊断、判断疾病发展与预后的一种新型标志物。本文对目前与TBI相关lncRNA作用机制的新进展进行综述。Traumatic brain injury(TBI)is the most prevalent acquired brain injury,featuring complex conditions,high disability and mortality rates,poor quality of life,and heavy economic burden.Early,rapid,and accurate diagnosis of TBI is of vital importance for actively and effectively guiding clinical treatment and determining prognosis.In recent years,it has been discovered that long noncoding RNAs(lncRNAs)exert various biological functions in TBI and can serve as a novel biomarker for the early diagnosis,disease development,and prognosis of TBI.This paper presents a review of the recent advancements in the mechanism of lncRNAs associated with TBI.

关 键 词：颅脑损伤 长链非编码RNA 生物标志物 治疗 

分 类 号：R651.15[医药卫生—外科学]