Effects of Hot Night Exposure on Human Semen Quality:A Multicenter Population-Based Study  

作　　者：Tingting Dai Ting Xu Qiling Wang Haobo Ni Chunying Song Yushan Li Fuping Li Tianqing Meng Huiqiang Sheng Lingxi Wang Xiaoyan Cai Lina Xiao Xiaolin Yu Qinghui Zeng Pi Guo Xinzong Zhang 

机构地区：[1]Department of Preventive Medicine,Shantou University Medical College,Shantou 515041,Guangdong,China [2]National Health Commission Key Laboratory of Male Reproduction and Genetics,Guangzhou 510600,Guangdong,China [3]Department of Andrology,Guangdong Provincial Reproductive Science Institute(Guangdong Provincial Fertility Hospital),Guangzhou 510600,Guangdong,China [4]Human Sperm Bank,the Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Taiyuan 030032,Shanxi,China [5]Human Sperm Bank,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan,China [6]Human Sperm Bank,the Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education,West China Second University Hospital of Sichuan University,Chengdu 610041,Sichuan,China [7]Reproductive Medicine Center,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China [8]Human Sperm Bank,Reproductive Medicine Center,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China [9]Human Sperm Bank,the Zhejiang Provincial Maternal and Child and Reproductive Health Care Center,Hangzhou 310012,Zhejiang,China

出　　处：《Biomedical and Environmental Sciences》2025年第2期178-193,共16页生物医学与环境科学(英文版)

基　　金：funded by the Guangdong Provincial Natural Science Foundation of China(No.2022A1515011517).

摘　　要：Objective To explore and quantify the association of hot night exposure during the sperm development period(0–90 lag days) with semen quality.Methods A total of 6,640 male sperm donors from 6 human sperm banks in China during 2014–2020were recruited in this multicenter study.Two indices(i.e.,hot night excess [HNE] and hot night duration[HND]) were used to estimate the heat intensity and duration during nighttime.Linear mixed models were used to examine the association between hot nights and semen quality parameters.Results The exposure-response relationship revealed that HNE and HND during 0–90 days before semen collection had a significantly inverse association with sperm motility.Specifically,a 1 ℃ increase in HNE was associated with decreased sperm progressive motility of 0.0090(95% confidence interval[CI]:–0.0147,–0.0033) and decreased total motility of 0.0094(95% CI:–0.0160,–0.0029).HND was significantly associated with reduced sperm progressive motility and total motility of 0.0021(95% CI:–0.0040,–0.0003) and 0.0023(95% CI:–0.0043,–0.0002),respectively.Consistent results were observed at different temperature thresholds on hot nights.Conclusion Our findings highlight the need to mitigate nocturnal heat exposure during spermatogenesis to maintain optimal semen quality.

关 键 词：Climate change Exposure-response relationship Hot night exposure Human semen quality Multicenter study 

分 类 号：R122.2[医药卫生—环境卫生学]