重庆地区汉族与土家族献血者多血型系统抗原分布调查  

Antigen distribution frequency of Han and Tujia polyhemia systems in

作　　者：尹鹏为 刘不尽[2] 崔丹荔 代华友 邹海曼 吴思其 黄霞[2] 徐永柱[1,2] YIN Pengwei;LIU Bujin;CUI Danli;DAI Huayou;ZOU Haiman;WU Siqi;HUANG Xia;XU Yongzhu(School of Public Health,Chongqing Medical University,Chongqing 400016;China,Chongqing Blood Center,Chongqing 400052,China)

机构地区：[1]重庆医科大学公共卫生学院,重庆400016 [2]重庆市血液中心,重庆400052

出　　处：《中国输血杂志》2025年第2期214-221,共8页Chinese Journal of Blood Transfusion

基　　金：重庆市自然科学基金(CSTB2022NSCQ-MSX1237);重庆市科卫联合医学科研项目(2022ZDXM031)。

摘　　要：目的了解重庆市汉族和土家族献血人群Rh、MNS、Kidd血型系统抗原表型分布规律,为建立献血者拓展血型抗原表型库和开展拓展血型配合性输注提供数据支持。方法采用试管法检测重庆市汉族和土家族献血人群Rh、MNS、Kidd血型系统抗原,并对3种血型系统进行Hardy-Weinborg吻合度检测计算。采用Pearson卡方检验和Fisher确切概率法比较不同地区、不同民族之间表型分布频率的差异。结果Rh血型系统抗原表型分布频率汉族和土家族献血者均为CCee>CcEe>Ccee>ccEE。土家族献血者CCee(52.02%)高于汉族献血者(47.24%),而汉族献血者CcEe(32.20%)高于土家族献血者(28.94%)。MNS血型系统抗原表型分布频率汉族和土家族献血者均为MN>MM>NN,Kidd血型系统抗原表型分布频率汉族和土家族献血者均为Jk(a+b+)分布频率最高,汉族Jk(a+b-)>Jk(a-b+),而土家族Jk(a-b+)>Jk(a+b-)。汉族和土家族献血者3种血型抗原符合Hardy-Weinberg平衡,(P>0.05)。汉族与土家族献血者的3种血型系统抗原表型频率无差异(P>0.05)。献血者Rh抗原表型分布频率,重庆与西安、浙江、汕头、佛山、南宁、扬州比较有差异(P<0.05),与广安和深圳比较无差异(P>0.05)。重庆献血者Rh抗原表型分布频率,汉族、土家族与藏族、蒙古族、朝鲜族、哈尼族比较有差异(P<0.05)。重庆汉族献血者MNS抗原表型分布频率,重庆与乌鲁木齐、海南、运城比较有差异(P<0.05),与西安、温州比较无差异(P>0.05)。重庆土家族献血者MNS抗原表型分布频率,重庆与乌鲁木齐、海南比较有差异(P<0.05),与西安、温州、运城比较无差异(P>0.05)。献血者Kidd抗原表型分布频率,重庆与哈尔滨比较有差异(P<0.05),与惠州、温州、宜昌比较无差异(P>0.05)。结论重庆地区人群有多民族特征,Rh、MNS、Kidd血型系统抗原表型存在多样性和地区差异,建立拓展血型库可以为临床精准输血提供更多的选择。Objective To analyse the distribution of antigen phenotypes in the Rh,MNS and Kidd blood group systems of Han and Tujia blood donors in Chongqing,and to provide data support for the establishment of an expanded blood group antigen phenotype database and the development of expanded blood group coordinated transfusion in blood donors.Methods The antigens of Rh,MNS and Kidd blood group systems in Han and Tujia blood donors in Chongqing were detected by test-tube method,and the Hardy-Weinborg anastomosis of the three blood group systems was calculated.Pearson′s chi-square test and Fisher′s exact probability method were used to compare the differences in phenotypic distribution frequencies among different regions and ethnic groups.Results Han and Tujia blood donors accounted for the highest proportion of CCee in the antigenic phenotype of the Rh blood group system,followed by CcEe,and then Ccee and ccEE.Tujia blood do-nors accounted for 52.02%of CCee,which was higher than that of Han blood donors(47.24%),while Han blood donors accounted for 32.20%of CcEe,which was higher than that of Tujia blood donors(28.94%).In the antigenic phenotype of the MNS blood group system,the blood donors of Han nationality and Tujia were MN>MM>NN,.The antigen phenotype dis-tribution frequency of the Kidd blood group system was highest for Jk(a+b+)among both Han and Tujia blood donors,and the blood donors of Han nationality were Jk(a+b+)>Jk(a+b+),while those of Tujia were Jk(a-b+)>Jk(a+b-).The an-tigens of the three blood groups of Han and Tujia blood donors were consistent with the Hardy-Weinberg balance(P>0.05).There was no statistically significant difference in the frequency of antigen phenotypes of the three blood group systems be-tween Han and Tujia blood donors(P>0.05).There were statistically significant differences in the phenotypic distribution frequency of Rh antigens between Chongqing and Xi′an,Zhejiang,Shantou,Foshan,Nanning and Yangzhou(P<0.05),but not with Guang′an and Shenzhen(P>0.05).There were statistically signifi

关 键 词：抗原频率 RH血型 MNS血型 KIDD血型 汉族 土家族 

分 类 号：R457.11[医药卫生—治疗学]