全局性调控因子LaeA在丝状真菌中的作用:机制与应用  

The Role of the Global Regulatory Factor LaeA in Filamentous Fungi:Mechanisms and Applications

作　　者：孟宪超 胡波 宁哲 孙园园 于豪冰 刘小宇 MENG Xianchao;HU Bo;NING Zhe;SUN Yuanyuan;YU Haobing;LIU Xiaoyu(Naval Medical Center,Naval Medical University,Shanghai 200433,China;School of Ocean Food and Biological Engineering,Jiangsu Ocean University,Jiangsu Lianyungang 222005,China)

机构地区：[1]海军军医大学海军特色医学中心,上海200433 [2]江苏海洋大学海洋食品与生物工程学院,江苏连云港222005

出　　处：《生物技术进展》2025年第1期27-34,共8页Current Biotechnology

基　　金：国家重点研发计划项目(2022YFC2804105)。

摘　　要：LaeA是丝状真菌中重要的全局性调控因子,通过调节相关基因的表达,控制菌株的生长发育或促进次级代谢产物的合成。近年来,随着生物信息学分析技术的发展,LaeA参与的新的调控作用被发现。聚焦于LaeA的作用机制和调控作用,从LaeA的结构功能、真菌生育和次级代谢产物的调节3个方面综述了LaeA在真菌中的研究进展,同时探讨了LaeA在药物研发、农业以及工业生产等领域的应用潜力,以期为提高丝状真菌次级代谢产物的产量、活性和多样性,以及开发新型的海洋药物等提供参考和借鉴。Loss of aflR expression-A(LaeA)has been recognized as a crucial global regulatory factor in filamentous fungi,orches⁃trating the intricate balance of gene expression to govern either the developmental trajectory of strains or the synthesis and diversi⁃fication of secondary metabolites.Recent advancements in bioinformatics analysis have unveiled numerous novel regulatory roles of LaeA.This review focused on elucidating the mechanisms and regulatory functions of LaeA,encompassing its structural-func⁃tional attributes and its modulation of fungal growth and secondary metabolite biosynthesis.Simultaneously,it explored the poten⁃tial applications of LaeA in the fields such as drug development,agriculture,and industrial production,in order to provide refer⁃ence and help in improving the yield and activity of secondary metabolites of filamentous fungi,and developing new marine drugs.

关 键 词：全局性调控因子LaeA 次级代谢 丝状真菌 

分 类 号：Q78[生物学—分子生物学] Q939.5